Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
KB (functional) | = 4 nM | Functional antagonism measured by its ability to block angiotensin II induced contractions in rabbit aortic smooth muscle strips | ChEMBL. | No reference |
Ki (binding) | = 6.3 nM | Binding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranes | ChEMBL. | No reference |
Max blood pressure fall (functional) | = 15 % | Tested for maximum percent blood pressure fall in salt depleted spontaneously hypertensive rat at a dose of 10 umol/kg po at 18-24 hr | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.