Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0142 | 0.3875 | 0.4433 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0129 | 0.3005 | 0.6048 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0142 | 0.3875 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0159 | 0.4968 | 1 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0142 | 0.3875 | 0.5 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0129 | 0.3005 | 0.7754 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0237 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0159 | 0.4968 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0159 | 0.4968 | 1 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0142 | 0.3875 | 0.5 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0142 | 0.3875 | 0.5 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0142 | 0.3875 | 0.5 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0142 | 0.3875 | 0.78 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0142 | 0.3875 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.