Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | trypanothione reductase | 0.0062 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 1 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0062 | 0 | 0.5 |
Toxoplasma gondii | thioredoxin reductase | 0.0062 | 0 | 0.5 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0062 | 0 | 0.5 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0062 | 0 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0107 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 1 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0062 | 0 | 0.5 |
Plasmodium vivax | glutathione reductase, putative | 0.0062 | 0 | 0.5 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0062 | 0 | 0.5 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0062 | 0 | 0.5 |
Brugia malayi | Fibroblast growth factor family protein | 0.0107 | 1 | 1 |
Leishmania major | trypanothione reductase | 0.0062 | 0 | 0.5 |
Plasmodium falciparum | thioredoxin reductase | 0.0062 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Delta blood pressure (functional) | = -27 mmHg | Difference in systolic blood pressure of SH rats observed prior to the first application and 2 hr after the fifth application at the oral dose of 5 mg/kg was expressed as Delta BP | ChEMBL. | 6492077 |
ED25 (functional) | = 0.1 mg kg-1 | Dose estimated to produce 25 mm Hg fall in mean systemic blood pressure of anesthetized cat at 10 min after administration | ChEMBL. | 6492077 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.