Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adenosine A1 receptor | Starlite/ChEMBL | References |
Homo sapiens | adenosine A2b receptor | Starlite/ChEMBL | References |
Homo sapiens | adenosine A2a receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | follicle stimulating hormone receptor | adenosine A2a receptor | 412 aa | 336 aa | 22.3 % |
Brugia malayi | hypothetical protein | adenosine A1 receptor | 326 aa | 305 aa | 21.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | transient receptor potential channel | 0.0012 | 0.5 | 0.5 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0012 | 0.5 | 0.5 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0012 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.5 | 0.5 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0012 | 0.5 | 0.5 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0012 | 0.5 | 0.5 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0012 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | Displacement of [125I]-AB-MECA from human A3 receptor expressed in CHO cells | ChEMBL. | 18226896 | |
Ki (binding) | 0 | Displacement of [125I]-AB-MECA from human A3 receptor expressed in CHO cells | ChEMBL. | 18226896 |
Ki (binding) | = 5 nM | Displacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranes | ChEMBL. | 18226896 |
Ki (binding) | = 5 nM | Displacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranes | ChEMBL. | 18226896 |
Ki (binding) | = 100 nM | Displacement of [3H]ZM241385 from human A2A receptor expressed in HEK293 cell membranes | ChEMBL. | 18226896 |
Ki (binding) | = 100 nM | Displacement of [3H]ZM241385 from human A2A receptor expressed in HEK293 cell membranes | ChEMBL. | 18226896 |
Ki (binding) | = 210 nM | Displacement of [3H]-CPX from human A1 receptor expressed in CHO cell membranes | ChEMBL. | 18226896 |
Ki (binding) | = 210 nM | Displacement of [3H]-CPX from human A1 receptor expressed in CHO cell membranes | ChEMBL. | 18226896 |
Ratio Ki (binding) | 0 | Selectivity for human A2B receptor over human A3 receptor | ChEMBL. | 18226896 |
Ratio Ki (binding) | = 20 | Selectivity for human A2B receptor over human A2A receptor | ChEMBL. | 18226896 |
Ratio Ki (binding) | = 42 | Selectivity for human A2B receptor over human A1 receptor | ChEMBL. | 18226896 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.