Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0443 | 0.5911 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0443 | 0.5911 | 0.5 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0443 | 0.5911 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0173 | 0.0427 | 0.0722 |
Echinococcus granulosus | cAMP specific 3'5' cyclic phosphodiesterase | 0.0173 | 0.0427 | 0.0722 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0443 | 0.5911 | 0.5 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0443 | 0.5911 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0443 | 0.5911 | 0.5728 |
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.0173 | 0.0427 | 0.0722 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0443 | 0.5911 | 0.5 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0443 | 0.5911 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0443 | 0.5911 | 0.5 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0443 | 0.5911 | 0.5 |
Echinococcus multilocularis | Serine:threonine protein kinase PLK4 | 0.0348 | 0.398 | 0.6733 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0443 | 0.5911 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0443 | 0.5911 | 0.5 |
Echinococcus granulosus | Serine:threonine protein kinase PLK4 | 0.0348 | 0.398 | 0.6733 |
Giardia lamblia | Kinase, PLK | 0.0443 | 0.5911 | 1 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0443 | 0.5911 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0443 | 0.5911 | 0.5 |
Toxoplasma gondii | 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein | 0.0173 | 0.0427 | 0.5 |
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.0173 | 0.0427 | 0.0722 |
Trypanosoma brucei | polo-like protein kinase | 0.0443 | 0.5911 | 0.5 |
Echinococcus granulosus | cAMP specific 3'5' cyclic phosphodiesterase | 0.0173 | 0.0427 | 0.0722 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0443 | 0.5911 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0443 | 0.5911 | 0.5 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0443 | 0.5911 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 0.053 uM | Induction of apoptosis in human SNU398 cells assessed as caspase-3 activation | ChEMBL. | 17950608 |
EC50 (functional) | = 0.053 uM | Induction of apoptosis in human SNU398 cells assessed as caspase-3 activation | ChEMBL. | 17950608 |
EC50 (functional) | = 0.14 uM | Induction of apoptosis in human T47D cells assessed as caspase-3 activation | ChEMBL. | 17950608 |
EC50 (functional) | = 0.14 uM | Induction of apoptosis in human T47D cells assessed as caspase-3 activation | ChEMBL. | 17950608 |
EC50 (functional) | = 0.33 uM | Induction of apoptosis in human HCT116 cells assessed as caspase-3 activation | ChEMBL. | 17950608 |
EC50 (functional) | = 0.33 uM | Induction of apoptosis in human HCT116 cells assessed as caspase-3 activation | ChEMBL. | 17950608 |
GI50 (functional) | = 0.14 uM | Antiproliferation activity against human SNU398 cells | ChEMBL. | 17950608 |
GI50 (functional) | = 0.14 uM | Antiproliferation activity against human SNU398 cells | ChEMBL. | 17950608 |
GI50 (functional) | = 0.59 uM | Antiproliferation activity against human T47D cells | ChEMBL. | 17950608 |
GI50 (functional) | = 0.59 uM | Antiproliferation activity against human T47D cells | ChEMBL. | 17950608 |
GI50 (functional) | = 0.93 uM | Antiproliferation activity against human HCT116 cells | ChEMBL. | 17950608 |
GI50 (functional) | = 0.93 uM | Antiproliferation activity against human HCT116 cells | ChEMBL. | 17950608 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 17950608 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.