Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | set domain proteins, putative | 0.0243 | 0.8743 | 0.5 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0114 | 0.3563 | 0.8756 |
Plasmodium falciparum | apurinic/apyrimidinic endonuclease Apn1, putative | 0.0079 | 0.2169 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0126 | 0.407 | 1 |
Mycobacterium tuberculosis | Probable reductase | 0.0114 | 0.3563 | 0.8756 |
Loa Loa (eye worm) | glutathione reductase | 0.005 | 0.1014 | 0.0785 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0126 | 0.407 | 1 |
Plasmodium vivax | apurinic/apyrimidinic endonuclease Apn1, putative | 0.0079 | 0.2169 | 1 |
Toxoplasma gondii | endonuclease IV APN | 0.0079 | 0.2169 | 1 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0114 | 0.3563 | 0.8756 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0214 | 0.7563 | 0.7501 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.005 | 0.1014 | 0.2493 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0114 | 0.3563 | 0.8756 |
Brugia malayi | DNA-(Apurinic or apyrimidinic site) lyase | 0.0079 | 0.2169 | 0.2625 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0114 | 0.3563 | 0.7335 |
Chlamydia trachomatis | endonuclease IV | 0.0079 | 0.2169 | 0.5 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0114 | 0.3563 | 0.8756 |
Leishmania major | trypanothione reductase | 0.005 | 0.1014 | 0.5 |
Toxoplasma gondii | thioredoxin reductase | 0.005 | 0.1014 | 0.3984 |
Loa Loa (eye worm) | thioredoxin reductase | 0.005 | 0.1014 | 0.0785 |
Brugia malayi | glutathione reductase | 0.005 | 0.1014 | 0.1046 |
Schistosoma mansoni | NAALADASE L peptidase (M28 family) | 0.0176 | 0.6046 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.2169 | 0.1969 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0126 | 0.407 | 1 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0031 | 0.0249 | 0.0556 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0114 | 0.3563 | 0.8756 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.005 | 0.1014 | 0.0806 |
Plasmodium vivax | thioredoxin reductase, putative | 0.005 | 0.1014 | 0.3984 |
Loa Loa (eye worm) | hypothetical protein | 0.025 | 0.9025 | 0.9 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.005 | 0.1014 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.6307 | 0.6212 |
Mycobacterium tuberculosis | Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) | 0.0079 | 0.2169 | 0.533 |
Echinococcus multilocularis | n acetylated alpha linked acidic dipeptidase 2 | 0.0268 | 0.9739 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.005 | 0.1014 | 0.3984 |
Mycobacterium ulcerans | endonuclease IV | 0.0079 | 0.2169 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0126 | 0.407 | 1 |
Onchocerca volvulus | 0.0243 | 0.8743 | 1 | |
Brugia malayi | Thioredoxin reductase | 0.005 | 0.1014 | 0.1046 |
Trypanosoma brucei | trypanothione reductase | 0.005 | 0.1014 | 0.5 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.005 | 0.1014 | 0.5 |
Brugia malayi | Pre-SET motif family protein | 0.0214 | 0.7563 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.85 uM | Blockade of human K+ channel in HEK293 cells assessed as inhibition of outward delayed rectifying K+ current | ChEMBL. | 18032041 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.