Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Protein kinase domain containing protein | 0.0829 | 0.9749 | 1 |
Brugia malayi | hypothetical protein | 0.0406 | 0.2436 | 0.2499 |
Loa Loa (eye worm) | hypothetical protein | 0.0406 | 0.2436 | 0.2499 |
Loa Loa (eye worm) | hypothetical protein | 0.0406 | 0.2436 | 0.2499 |
Loa Loa (eye worm) | hypothetical protein | 0.0829 | 0.9749 | 1 |
Brugia malayi | hypothetical protein | 0.0406 | 0.2436 | 0.2499 |
Loa Loa (eye worm) | hypothetical protein | 0.0406 | 0.2436 | 0.2499 |
Loa Loa (eye worm) | hypothetical protein | 0.0406 | 0.2436 | 0.2499 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0406 | 0.2436 | 0.2499 |
Loa Loa (eye worm) | hypothetical protein | 0.0406 | 0.2436 | 0.2499 |
Loa Loa (eye worm) | hypothetical protein | 0.0406 | 0.2436 | 0.2499 |
Loa Loa (eye worm) | hypothetical protein | 0.0406 | 0.2436 | 0.2499 |
Loa Loa (eye worm) | hypothetical protein | 0.0406 | 0.2436 | 0.2499 |
Loa Loa (eye worm) | hypothetical protein | 0.0406 | 0.2436 | 0.2499 |
Brugia malayi | Melatonin receptor type 1A | 0.0406 | 0.2436 | 0.2499 |
Brugia malayi | putative neuropeptide receptor | 0.0406 | 0.2436 | 0.2499 |
Onchocerca volvulus | 0.0406 | 0.2436 | 0.5 | |
Onchocerca volvulus | 0.0406 | 0.2436 | 0.5 | |
Echinococcus multilocularis | mitogen activated protein kinase kinase kinase | 0.0829 | 0.9749 | 1 |
Brugia malayi | G protein-coupled receptor | 0.0406 | 0.2436 | 0.2499 |
Loa Loa (eye worm) | hypothetical protein | 0.0406 | 0.2436 | 0.2499 |
Onchocerca volvulus | 0.0406 | 0.2436 | 0.5 | |
Brugia malayi | G protein-coupled receptor F59B2.13 | 0.0406 | 0.2436 | 0.2499 |
Loa Loa (eye worm) | hypothetical protein | 0.0406 | 0.2436 | 0.2499 |
Brugia malayi | neuropeptide F receptor | 0.0406 | 0.2436 | 0.2499 |
Brugia malayi | neuropeptide F receptor | 0.0406 | 0.2436 | 0.2499 |
Onchocerca volvulus | 0.0406 | 0.2436 | 0.5 | |
Onchocerca volvulus | 0.0406 | 0.2436 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0406 | 0.2436 | 0.2499 |
Brugia malayi | hypothetical protein | 0.0406 | 0.2436 | 0.2499 |
Loa Loa (eye worm) | hypothetical protein | 0.0829 | 0.9749 | 1 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0406 | 0.2436 | 0.2499 |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0406 | 0.2436 | 0.5 |
Brugia malayi | GnHR receptor homolog | 0.0406 | 0.2436 | 0.2499 |
Onchocerca volvulus | 0.0406 | 0.2436 | 0.5 | |
Brugia malayi | Tachykinin-like peptides receptor 99D | 0.0406 | 0.2436 | 0.2499 |
Brugia malayi | Dopamine receptor protein 1 | 0.0406 | 0.2436 | 0.2499 |
Loa Loa (eye worm) | hypothetical protein | 0.0406 | 0.2436 | 0.2499 |
Brugia malayi | ORL1-like opioid receptor | 0.0406 | 0.2436 | 0.2499 |
Loa Loa (eye worm) | hypothetical protein | 0.0406 | 0.2436 | 0.2499 |
Loa Loa (eye worm) | hypothetical protein | 0.0406 | 0.2436 | 0.2499 |
Loa Loa (eye worm) | hypothetical protein | 0.0406 | 0.2436 | 0.2499 |
Loa Loa (eye worm) | hypothetical protein | 0.0406 | 0.2436 | 0.2499 |
Loa Loa (eye worm) | hypothetical protein | 0.0406 | 0.2436 | 0.2499 |
Brugia malayi | G-protein coupled receptor | 0.0406 | 0.2436 | 0.2499 |
Loa Loa (eye worm) | hypothetical protein | 0.0406 | 0.2436 | 0.2499 |
Loa Loa (eye worm) | hypothetical protein | 0.0406 | 0.2436 | 0.2499 |
Loa Loa (eye worm) | hypothetical protein | 0.0406 | 0.2436 | 0.2499 |
Loa Loa (eye worm) | hypothetical protein | 0.0406 | 0.2436 | 0.2499 |
Loa Loa (eye worm) | hypothetical protein | 0.0406 | 0.2436 | 0.2499 |
Loa Loa (eye worm) | hypothetical protein | 0.0406 | 0.2436 | 0.2499 |
Loa Loa (eye worm) | hypothetical protein | 0.0406 | 0.2436 | 0.2499 |
Loa Loa (eye worm) | hypothetical protein | 0.0406 | 0.2436 | 0.2499 |
Loa Loa (eye worm) | hypothetical protein | 0.0406 | 0.2436 | 0.2499 |
Brugia malayi | AKH receptor | 0.0406 | 0.2436 | 0.2499 |
Onchocerca volvulus | 0.0406 | 0.2436 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0406 | 0.2436 | 0.2499 |
Loa Loa (eye worm) | hypothetical protein | 0.0406 | 0.2436 | 0.2499 |
Brugia malayi | Dopamine receptor protein 2 | 0.0406 | 0.2436 | 0.2499 |
Loa Loa (eye worm) | G-protein-linked acetylcholine receptor protein 2 | 0.0406 | 0.2436 | 0.2499 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0406 | 0.2436 | 0.2499 |
Loa Loa (eye worm) | TKL/MLK/LZK protein kinase | 0.0829 | 0.9749 | 1 |
Brugia malayi | hypothetical protein | 0.0406 | 0.2436 | 0.2499 |
Brugia malayi | Serotonin receptor | 0.0406 | 0.2436 | 0.2499 |
Loa Loa (eye worm) | TYRA-2 protein | 0.0406 | 0.2436 | 0.2499 |
Brugia malayi | gonadotropin-releasing hormone receptor 2 | 0.0406 | 0.2436 | 0.2499 |
Onchocerca volvulus | 0.0406 | 0.2436 | 0.5 | |
Onchocerca volvulus | 0.0406 | 0.2436 | 0.5 | |
Loa Loa (eye worm) | melatonin receptor type 1A | 0.0406 | 0.2436 | 0.2499 |
Loa Loa (eye worm) | hypothetical protein | 0.0406 | 0.2436 | 0.2499 |
Brugia malayi | Serotonin/octopamine receptor family protein 7 | 0.0406 | 0.2436 | 0.2499 |
Brugia malayi | sulfakinin receptor protein | 0.0406 | 0.2436 | 0.2499 |
Loa Loa (eye worm) | 5-hydroxytryptamine 2C receptor | 0.0406 | 0.2436 | 0.2499 |
Onchocerca volvulus | 0.0406 | 0.2436 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0406 | 0.2436 | 0.2499 |
Loa Loa (eye worm) | unidentified vitellogenin-linked transcript protein 6 | 0.0406 | 0.2436 | 0.2499 |
Brugia malayi | hypothetical protein | 0.0406 | 0.2436 | 0.2499 |
Loa Loa (eye worm) | hypothetical protein | 0.0406 | 0.2436 | 0.2499 |
Onchocerca volvulus | 0.0406 | 0.2436 | 0.5 | |
Loa Loa (eye worm) | gonadotropin-releasing hormone receptor 2 | 0.0406 | 0.2436 | 0.2499 |
Echinococcus granulosus | mitogen activated protein kinase kinase kinase | 0.0829 | 0.9749 | 1 |
Onchocerca volvulus | 0.0406 | 0.2436 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0406 | 0.2436 | 0.2499 |
Onchocerca volvulus | 0.0406 | 0.2436 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0406 | 0.2436 | 0.2499 |
Onchocerca volvulus | 0.0406 | 0.2436 | 0.5 | |
Brugia malayi | G-protein-linked acetylcholine receptor protein 2, putative | 0.0406 | 0.2436 | 0.2499 |
Loa Loa (eye worm) | hypothetical protein | 0.0406 | 0.2436 | 0.2499 |
Loa Loa (eye worm) | hypothetical protein | 0.0406 | 0.2436 | 0.2499 |
Onchocerca volvulus | 0.0406 | 0.2436 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0406 | 0.2436 | 0.2499 |
Loa Loa (eye worm) | hypothetical protein | 0.0406 | 0.2436 | 0.2499 |
Brugia malayi | hypothetical protein | 0.0406 | 0.2436 | 0.2499 |
Brugia malayi | putative neuropeptide receptor NPR1 | 0.0406 | 0.2436 | 0.2499 |
Loa Loa (eye worm) | hypothetical protein | 0.0406 | 0.2436 | 0.2499 |
Brugia malayi | Dopamine receptor protein 1, putative (partial) | 0.0406 | 0.2436 | 0.2499 |
Loa Loa (eye worm) | hypothetical protein | 0.0406 | 0.2436 | 0.2499 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0406 | 0.2436 | 0.2499 |
Onchocerca volvulus | 0.0406 | 0.2436 | 0.5 | |
Brugia malayi | Dopamine receptor | 0.0406 | 0.2436 | 0.2499 |
Brugia malayi | follicle stimulating hormone receptor | 0.0406 | 0.2436 | 0.2499 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0406 | 0.2436 | 0.2499 |
Loa Loa (eye worm) | hypothetical protein | 0.0406 | 0.2436 | 0.2499 |
Brugia malayi | Serotonin receptor | 0.0406 | 0.2436 | 0.2499 |
Loa Loa (eye worm) | hypothetical protein | 0.0406 | 0.2436 | 0.2499 |
Brugia malayi | larval opioid receptor | 0.0406 | 0.2436 | 0.2499 |
Brugia malayi | G-protein coupled receptor | 0.0406 | 0.2436 | 0.2499 |
Loa Loa (eye worm) | hypothetical protein | 0.0406 | 0.2436 | 0.2499 |
Loa Loa (eye worm) | hypothetical protein | 0.0406 | 0.2436 | 0.2499 |
Loa Loa (eye worm) | hypothetical protein | 0.0406 | 0.2436 | 0.2499 |
Loa Loa (eye worm) | hypothetical protein | 0.0406 | 0.2436 | 0.2499 |
Brugia malayi | RE15519p | 0.0406 | 0.2436 | 0.2499 |
Loa Loa (eye worm) | hypothetical protein | 0.0406 | 0.2436 | 0.2499 |
Loa Loa (eye worm) | hypothetical protein | 0.0406 | 0.2436 | 0.2499 |
Loa Loa (eye worm) | hypothetical protein | 0.0406 | 0.2436 | 0.2499 |
Brugia malayi | Unidentified vitellogenin-linked transcript protein 6, putative | 0.0406 | 0.2436 | 0.2499 |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0406 | 0.2436 | 0.5 |
Onchocerca volvulus | 0.0406 | 0.2436 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Antiviral index (functional) | > 6 | Ratio of ID50 for dThd or dUrd incorporation to ID50 for HSV-1, HSV-2 or VV(whatever was lowest) | ChEMBL. | 6092636 |
IC50 (ADMET) | > 200 uM | Cytotoxicity against mouse L1210/0 cells after 48 hrs | ChEMBL. | 17341060 |
ID50 (functional) | = 70 ug ml-1 | Concentration required to reduce cytopathogenicity of Herpes simplex virus type 1 (strain KOS) by 50% in primary rabbit kidney (PRK) cells | ChEMBL. | 6092636 |
ID50 (functional) | = 350 ug ml-1 | Inhibitory concentration required to reduce cell growth of Murine Leukemia L1210 cells | ChEMBL. | 6092636 |
ID50 (functional) | = 350 ug ml-1 | Inhibitory concentration required to reduce cell growth of Murine Leukemia L1210 cells | ChEMBL. | 6092636 |
ID50 (functional) | > 400 ug ml-1 | Concentration required to reduce cytopathogenicity of Herpes simplex virus type 2 (strain G) by 50% in primary rabbit kidney (PRK) cells | ChEMBL. | 6092636 |
ID50 (functional) | > 400 ug ml-1 | Concentration required to reduce cytopathogenicity of vaccinia virus by 50% in primary rabbit kidney (PRK) cells | ChEMBL. | 6092636 |
ID50 (functional) | > 400 ug ml-1 | Concentration required to reduce cytopathogenicity of Vesicular stomatitis virus by 50% in primary rabbit kidney (PRK) cells | ChEMBL. | 6092636 |
ID50 (functional) | > 400 ug ml-1 | Inhibitory concentration required to reduce incorporation of 2-deoxythymidine (dThd) into DNA of Primary Rabbit kidney (PRK) cell cultures | ChEMBL. | 6092636 |
ID50 (functional) | > 400 ug ml-1 | Inhibitory concentration required to reduce 2-deoxyuridine ([3H-1'2']dUrd) incorporation into DNA of Primary Rabbit kidney (PRK) cell cultures | ChEMBL. | 6092636 |
ID50 (functional) | > 1000 ug ml-1 | Inhibitory concentration required to reduce [3H-methyl]-dThd C incorporation into cellular DNA by 50% in Murine Leukemia L1210 cells | ChEMBL. | 6092636 |
ID50 (functional) | > 1000 ug ml-1 | Inhibitory concentration required to reduce [3H1',2']dUrd incorporation into cellular DNA by 50% in Murine Leukemia L1210 cells | ChEMBL. | 6092636 |
ID50 (functional) | > 1000 ug ml-1 | Inhibitory concentration required to reduce [3H-methyl]-dThd C incorporation into cellular DNA by 50% in Murine Leukemia L1210 cells | ChEMBL. | 6092636 |
ID50 (functional) | > 1000 ug ml-1 | Inhibitory concentration required to reduce [3H1',2']dUrd incorporation into cellular DNA by 50% in Murine Leukemia L1210 cells | ChEMBL. | 6092636 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.