Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | complement component 1, s subcomponent | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | kinesin-5 | 0.0058 | 0.0973 | 0.5 |
Echinococcus granulosus | Tolloid protein 1 | 0.0021 | 0.011 | 0.011 |
Brugia malayi | Kinesin motor domain containing protein | 0.0058 | 0.0973 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.011 | 0.1127 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.0021 | 0.011 | 0.0127 |
Loa Loa (eye worm) | kinesin-like protein KLP2 | 0.0058 | 0.0973 | 1 |
Entamoeba histolytica | kinesin, putative | 0.0058 | 0.0973 | 0.5 |
Toxoplasma gondii | kinesin motor domain-containing protein | 0.0058 | 0.0973 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0388 | 0.8652 | 1 |
Echinococcus multilocularis | Tolloid protein 1 | 0.0021 | 0.011 | 0.011 |
Echinococcus multilocularis | kinesin family 1 | 0.0446 | 1 | 1 |
Plasmodium falciparum | kinesin-5 | 0.0058 | 0.0973 | 0.5 |
Schistosoma mansoni | kinesin eg-5 | 0.0058 | 0.0973 | 0.1124 |
Onchocerca volvulus | Arrow homolog | 0.0016 | 0 | 0.5 |
Giardia lamblia | Kinesin-5 | 0.0058 | 0.0973 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0374 | 0.3844 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.0021 | 0.011 | 0.1127 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CL (ADMET) | = 283 ml/min.kg | Clearance in rat at 2 mg/kg, iv | ChEMBL. | 18242991 |
Inhibition (binding) | = 66 % | Inhibition of human ERG at 10 uM by patch clamp assay | ChEMBL. | 18242991 |
Inhibition (binding) | = 66 % | Inhibition of human ERG at 10 uM by patch clamp assay | ChEMBL. | 18242991 |
Inhibition (binding) | = 69 % | Inhibition of adrenergic alpha1 receptor (unknown origin) at 10 uM | ChEMBL. | 18242991 |
Inhibition (binding) | = 74 % | Inhibition of dopamine transporter (unknown origin) at 10 uM | ChEMBL. | 18242991 |
Inhibition (binding) | = 74 % | Inhibition of dopamine transporter (unknown origin) at 10 uM | ChEMBL. | 18242991 |
Inhibition (binding) | = 76 % | Inhibition of opiate receptor at (unknown origin) 10 uM | ChEMBL. | 18242991 |
Inhibition (binding) | = 83 % | Inhibition of sodium channel site 2 (unknown origin) at 10 uM | ChEMBL. | 18242991 |
Inhibition (binding) | = 95 % | Inhibition of muscarinic receptor (unknown origin) at 10 uM | ChEMBL. | 18242991 |
Ki (binding) | = 40 nM | Inhibition of Complement C1s subcomponent (unknown origin) | ChEMBL. | 18242991 |
Ki (binding) | = 40 nM | Inhibition of Complement C1s subcomponent (unknown origin) | ChEMBL. | 18242991 |
Solubility | = 22 uM | Aqueous solubility of the compound at physiological pH | ChEMBL. | 18242991 |
t1/2 (ADMET) | = 2 hr | Half life in rat at 2 mg/kg, iv | ChEMBL. | 18242991 |
Vd (ADMET) | = 15 L/Kg | Volume of distribution in rat at 2 mg/kg, iv | ChEMBL. | 18242991 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.