Detailed information for compound 506467

Basic information

Technical information
  • TDR Targets ID: 506467
  • Name: 3,4,5-trihydroxybenzaldehyde
  • MW: 154.12 | Formula: C7H6O4
  • H donors: 3 H acceptors: 4 LogP: 0.32 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=Cc1cc(O)c(c(c1)O)O
  • InChi: 1S/C7H6O4/c8-3-4-1-5(9)7(11)6(10)2-4/h1-3,9-11H
  • InChiKey: RGZHEOWNTDJLAQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 13677-79-7
  • Gallaldehyde
  • NSC153692
  • EINECS 237-168-1
  • InChI=1/C7H6O4/c8-3-4-1-5(9)7(11)6(10)2-4/h1-3,9-11
  • benzaldehyde, 3,4,5-trihydroxy-
  • ZINC01564659

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Vibrio harveyi Autoinducer 2-binding periplasmic protein luxP Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0083 0.0719 0.1726
Loa Loa (eye worm) hypothetical protein 0.0083 0.0719 0.1726
Schistosoma mansoni neuropeptide receptor 0.0083 0.0719 0.0719
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0083 0.0719 0.1726
Onchocerca volvulus Neuropeptide F receptor homolog 0.0083 0.0719 0.2371
Echinococcus granulosus rhodopsin orphan GPCR 0.0083 0.0719 0.1726
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0083 0.0719 0.1726
Loa Loa (eye worm) hypothetical protein 0.0083 0.0719 0.1726
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0083 0.0719 0.0719
Echinococcus granulosus tm gpcr rhodopsin 0.0083 0.0719 0.1726
Echinococcus granulosus g protein coupled receptor 0.0083 0.0719 0.1726
Brugia malayi sulfakinin receptor protein 0.0083 0.0719 0.2753
Schistosoma mansoni opsin-like receptor 0.0083 0.0719 0.0719
Echinococcus granulosus 7tm_1 domain containing protein 0.0083 0.0719 0.1726
Loa Loa (eye worm) hypothetical protein 0.0083 0.0719 0.1726
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0083 0.0719 0.0719
Echinococcus multilocularis g-protein coupled receptor 0.0083 0.0719 0.1726
Echinococcus granulosus biogenic amine 5HT receptor 0.0329 0.4166 1
Loa Loa (eye worm) neuropeptide F receptor 0.0083 0.0719 0.1726
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0083 0.0719 0.0719
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0083 0.0719 0.0719
Echinococcus granulosus neuropeptide Y receptor 0.0083 0.0719 0.1726
Onchocerca volvulus 0.0083 0.0719 0.2371
Trichomonas vaginalis set domain proteins, putative 0.0248 0.3033 0.5
Loa Loa (eye worm) hypothetical protein 0.0083 0.0719 0.1726
Schistosoma mansoni biogenic amine receptor 0.0083 0.0719 0.0719
Echinococcus multilocularis neuropeptide s receptor 0.0083 0.0719 0.1726
Loa Loa (eye worm) hypothetical protein 0.0083 0.0719 0.1726
Echinococcus granulosus rhodopsin orphan GPCR 0.0083 0.0719 0.1726
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0083 0.0719 0.1726
Onchocerca volvulus 0.0083 0.0719 0.2371
Loa Loa (eye worm) hypothetical protein 0.0083 0.0719 0.1726
Echinococcus granulosus serotonin receptor 0.0083 0.0719 0.1726
Schistosoma mansoni opsin-like receptor 0.0083 0.0719 0.0719
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0083 0.0719 0.0719
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0083 0.0719 0.2753
Brugia malayi hypothetical protein 0.0083 0.0719 0.2753
Brugia malayi Tachykinin-like peptides receptor 99D 0.0083 0.0719 0.2753
Brugia malayi hypothetical protein 0.0083 0.0719 0.2753
Schistosoma mansoni hypothetical protein 0.0083 0.0719 0.0719
Schistosoma mansoni amine GPCR 0.0083 0.0719 0.0719
Echinococcus multilocularis neuropeptides capa receptor 0.0083 0.0719 0.1726
Schistosoma mansoni growth hormone secretagogue receptor 0.0083 0.0719 0.0719
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0218 0.2612 0.627
Echinococcus multilocularis rhodopsin orphan GPCR 0.0083 0.0719 0.1726
Echinococcus multilocularis orexin receptor type 2 0.0083 0.0719 0.1726
Echinococcus granulosus somatostatin receptor 0.0083 0.0719 0.1726
Echinococcus multilocularis rhodopsin orphan GPCR 0.0083 0.0719 0.1726
Brugia malayi ORL1-like opioid receptor 0.0083 0.0719 0.2753
Onchocerca volvulus 0.0083 0.0719 0.2371
Schistosoma mansoni neuropeptide F-like receptor 0.0083 0.0719 0.0719
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0083 0.0719 0.1726
Onchocerca volvulus 0.0083 0.0719 0.2371
Loa Loa (eye worm) hypothetical protein 0.0083 0.0719 0.1726
Brugia malayi Dopamine receptor protein 1 0.0083 0.0719 0.2753
Loa Loa (eye worm) hypothetical protein 0.0083 0.0719 0.1726
Brugia malayi GnHR receptor homolog 0.0083 0.0719 0.2753
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0083 0.0719 0.0719
Brugia malayi hypothetical protein 0.0083 0.0719 0.2753
Loa Loa (eye worm) TYRA-2 protein 0.0083 0.0719 0.1726
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0083 0.0719 0.0719
Echinococcus multilocularis fmrfamide receptor 0.0083 0.0719 0.1726
Onchocerca volvulus 0.0083 0.0719 0.2371
Echinococcus granulosus g-protein coupled receptor 0.0083 0.0719 0.1726
Echinococcus granulosus rhodopsin orphan GPCR 0.0083 0.0719 0.1726
Schistosoma mansoni amine GPCR 0.0083 0.0719 0.0719
Brugia malayi larval opioid receptor 0.0083 0.0719 0.2753
Loa Loa (eye worm) hypothetical protein 0.0083 0.0719 0.1726
Echinococcus granulosus tm gpcr rhodopsin 0.0083 0.0719 0.1726
Loa Loa (eye worm) hypothetical protein 0.0083 0.0719 0.1726
Echinococcus granulosus neuropeptide Y receptor 0.0083 0.0719 0.1726
Echinococcus multilocularis g protein coupled receptor 0.0083 0.0719 0.1726
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0083 0.0719 0.1726
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0083 0.0719 0.1726
Loa Loa (eye worm) hypothetical protein 0.0083 0.0719 0.1726
Onchocerca volvulus 0.0083 0.0719 0.2371
Echinococcus multilocularis fmrfamide receptor 0.0083 0.0719 0.1726
Brugia malayi G protein-coupled receptor 0.0083 0.0719 0.2753
Echinococcus multilocularis neuropeptide Y receptor 0.0083 0.0719 0.1726
Loa Loa (eye worm) hypothetical protein 0.0083 0.0719 0.1726
Echinococcus granulosus neuropeptides capa receptor 0.0083 0.0719 0.1726
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0083 0.0719 0.0719
Echinococcus multilocularis serotonin receptor 0.0329 0.4166 1
Echinococcus multilocularis serotonin receptor 0.0329 0.4166 1
Echinococcus granulosus neuropeptide s receptor 0.0083 0.0719 0.1726
Schistosoma mansoni alpha-1 adrenergic receptor 0.0083 0.0719 0.0719
Brugia malayi neuropeptide F receptor 0.0083 0.0719 0.2753
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0083 0.0719 0.2753
Echinococcus multilocularis g protein coupled receptor 0.0083 0.0719 0.1726
Echinococcus granulosus rhodopsin orphan GPCR 0.0083 0.0719 0.1726
Brugia malayi hypothetical protein 0.0083 0.0719 0.2753
Loa Loa (eye worm) hypothetical protein 0.0083 0.0719 0.1726
Echinococcus granulosus G protein coupled receptor 139 0.0083 0.0719 0.1726
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0083 0.0719 0.2753
Echinococcus granulosus 7TM GPCR rhodopsin 0.0083 0.0719 0.1726
Loa Loa (eye worm) hypothetical protein 0.0083 0.0719 0.1726
Plasmodium vivax SET domain protein, putative 0.0031 0 0.5
Onchocerca volvulus 0.0083 0.0719 0.2371
Loa Loa (eye worm) G-protein coupled receptor 0.0083 0.0719 0.1726
Loa Loa (eye worm) hypothetical protein 0.0083 0.0719 0.1726
Loa Loa (eye worm) hypothetical protein 0.0083 0.0719 0.1726
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0083 0.0719 0.0719
Schistosoma mansoni neuropeptide receptor 0.0083 0.0719 0.0719
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0083 0.0719 0.1726
Loa Loa (eye worm) hypothetical protein 0.0083 0.0719 0.1726
Echinococcus multilocularis G-protein coupled receptor, putative 0.0083 0.0719 0.1726
Echinococcus granulosus peptide allatostatin:somatostatin 0.0083 0.0719 0.1726
Echinococcus multilocularis rhodopsin orphan GPCR 0.0083 0.0719 0.1726
Schistosoma mansoni myosin xvIII 0.0083 0.0719 0.0719
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0083 0.0719 0.2371
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0083 0.0719 0.1726
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0083 0.0719 0.0719
Onchocerca volvulus 0.0083 0.0719 0.2371
Brugia malayi AKH receptor 0.0083 0.0719 0.2753
Loa Loa (eye worm) hypothetical protein 0.0083 0.0719 0.1726
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0083 0.0719 0.0719
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0083 0.0719 0.0719
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0083 0.0719 0.0719
Loa Loa (eye worm) hypothetical protein 0.0083 0.0719 0.1726
Loa Loa (eye worm) hypothetical protein 0.0083 0.0719 0.1726
Echinococcus granulosus tachykinin peptides receptor 99D 0.0083 0.0719 0.1726
Echinococcus granulosus allatostatin A receptor 0.0083 0.0719 0.1726
Brugia malayi Dopamine receptor 0.0083 0.0719 0.2753
Loa Loa (eye worm) hypothetical protein 0.0083 0.0719 0.1726
Loa Loa (eye worm) hypothetical protein 0.0329 0.4166 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0083 0.0719 0.1726
Echinococcus multilocularis dro:myosuppressin receptor 0.0083 0.0719 0.1726
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0083 0.0719 0.0719
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0083 0.0719 0.1726
Echinococcus granulosus dro:myosuppressin receptor 0.0083 0.0719 0.1726
Onchocerca volvulus 0.0083 0.0719 0.2371
Loa Loa (eye worm) hypothetical protein 0.0083 0.0719 0.1726
Loa Loa (eye worm) neuropeptide F receptor 0.0083 0.0719 0.1726
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0083 0.0719 0.0719
Brugia malayi hypothetical protein 0.0083 0.0719 0.2753
Echinococcus granulosus rhodopsin orphan GPCR 0.0083 0.0719 0.1726
Mycobacterium leprae Possible D-ribose-binding protein 0.0322 0.407 0.5
Echinococcus granulosus neuropeptide receptor 0.0083 0.0719 0.1726
Echinococcus multilocularis neuropeptide receptor 0.0083 0.0719 0.1726
Schistosoma mansoni adenoreceptor 0.0083 0.0719 0.0719
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0083 0.0719 0.0719
Loa Loa (eye worm) hypothetical protein 0.0083 0.0719 0.1726
Loa Loa (eye worm) hypothetical protein 0.0083 0.0719 0.1726
Schistosoma mansoni opsin-like receptor 0.0083 0.0719 0.0719
Loa Loa (eye worm) hypothetical protein 0.0083 0.0719 0.1726
Onchocerca volvulus 0.0248 0.3033 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0083 0.0719 0.2753
Echinococcus granulosus neuropeptide FF receptor 2 0.0083 0.0719 0.1726
Schistosoma mansoni amine GPCR 0.0083 0.0719 0.0719
Brugia malayi putative neuropeptide receptor 0.0083 0.0719 0.2753
Brugia malayi hypothetical protein 0.0083 0.0719 0.2753
Schistosoma mansoni neuropeptide receptor 0.0083 0.0719 0.0719
Treponema pallidum methylgalactoside ABC transporter, periplasmic galactose-binding protein (mglB-2) 0.0322 0.407 0.5
Onchocerca volvulus 0.0083 0.0719 0.2371
Schistosoma mansoni neuropeptide f receptor 76f 0.0083 0.0719 0.0719
Loa Loa (eye worm) hypothetical protein 0.0083 0.0719 0.1726
Schistosoma mansoni biogenic amine receptor 0.0083 0.0719 0.0719
Echinococcus multilocularis G protein coupled receptor 139 0.0083 0.0719 0.1726
Loa Loa (eye worm) hypothetical protein 0.0083 0.0719 0.1726
Echinococcus granulosus g protein coupled receptor 0.0083 0.0719 0.1726
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0083 0.0719 0.1726
Echinococcus granulosus sex peptide receptor 0.0083 0.0719 0.1726
Schistosoma mansoni biogenic amine receptor 0.0083 0.0719 0.0719
Echinococcus multilocularis rhodopsin orphan GPCR 0.0083 0.0719 0.1726
Onchocerca volvulus 0.0083 0.0719 0.2371
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0 0.5
Schistosoma mansoni amine GPCR 0.0083 0.0719 0.0719
Loa Loa (eye worm) hypothetical protein 0.0083 0.0719 0.1726
Brugia malayi neuropeptide F receptor 0.0083 0.0719 0.2753
Loa Loa (eye worm) hypothetical protein 0.0083 0.0719 0.1726
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0083 0.0719 0.1726
Echinococcus multilocularis neuropeptides capa receptor 0.0083 0.0719 0.1726
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0083 0.0719 0.1726
Loa Loa (eye worm) hypothetical protein 0.0083 0.0719 0.1726
Treponema pallidum methylgalactoside ABC transporter, periplasmic galactose-binding protein (mglB-1) 0.0322 0.407 0.5
Brugia malayi hypothetical protein 0.0083 0.0719 0.2753
Onchocerca volvulus 0.0083 0.0719 0.2371
Brugia malayi Pre-SET motif family protein 0.0218 0.2612 1
Loa Loa (eye worm) hypothetical protein 0.0083 0.0719 0.1726
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0083 0.0719 0.1726
Echinococcus multilocularis sex peptide receptor 0.0083 0.0719 0.1726
Brugia malayi G-protein coupled receptor 0.0083 0.0719 0.2753
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0083 0.0719 0.1726
Schistosoma mansoni hypothetical protein 0.0083 0.0719 0.0719
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0083 0.0719 0.1726
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0083 0.0719 0.0719
Echinococcus multilocularis neuropeptide receptor 0.0083 0.0719 0.1726
Echinococcus granulosus rhodopsin orphan GPCR 0.0083 0.0719 0.1726
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0083 0.0719 0.0719
Echinococcus granulosus alpha 1A adrenergic receptor 0.0083 0.0719 0.1726
Echinococcus granulosus neuropeptide receptor 0.0083 0.0719 0.1726
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0083 0.0719 0.2753
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0083 0.0719 0.1726
Schistosoma mansoni hypothetical protein 0.0083 0.0719 0.0719
Brugia malayi putative neuropeptide receptor NPR1 0.0083 0.0719 0.2753
Brugia malayi Serotonin receptor 0.0083 0.0719 0.2753
Brugia malayi hypothetical protein 0.0083 0.0719 0.2753
Loa Loa (eye worm) hypothetical protein 0.0083 0.0719 0.1726
Echinococcus multilocularis rhodopsin orphan GPCR 0.0083 0.0719 0.1726
Loa Loa (eye worm) hypothetical protein 0.0083 0.0719 0.1726
Echinococcus granulosus rhodopsin orphan GPCR 0.0083 0.0719 0.1726
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0083 0.0719 0.1726
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0083 0.0719 0.1726
Echinococcus granulosus tm gpcr rhodopsin 0.0083 0.0719 0.1726
Echinococcus granulosus g protein coupled receptor 0.0083 0.0719 0.1726
Loa Loa (eye worm) hypothetical protein 0.0329 0.4166 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0083 0.0719 0.1726
Echinococcus multilocularis neuropeptide FF receptor 2 0.0083 0.0719 0.1726
Schistosoma mansoni biogenic amine (5HT) receptor 0.0329 0.4166 0.4166
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0083 0.0719 0.0719
Brugia malayi hypothetical protein 0.0083 0.0719 0.2753
Brugia malayi G-protein coupled receptor 0.0083 0.0719 0.2753
Echinococcus multilocularis g protein coupled receptor 0.0083 0.0719 0.1726
Brugia malayi Serotonin receptor 0.0083 0.0719 0.2753
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0083 0.0719 0.0719
Brugia malayi hypothetical protein 0.0083 0.0719 0.2753
Brugia malayi Melatonin receptor type 1A 0.0083 0.0719 0.2753
Schistosoma mansoni neuropeptide F-like receptor 0.0083 0.0719 0.0719
Schistosoma mansoni histamine h1 receptor 0.0083 0.0719 0.0719
Onchocerca volvulus 0.0083 0.0719 0.2371
Schistosoma mansoni hypothetical protein 0.0083 0.0719 0.0719
Brugia malayi RE15519p 0.0083 0.0719 0.2753
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0083 0.0719 0.1726
Echinococcus granulosus neuropeptides capa receptor 0.0083 0.0719 0.1726
Echinococcus granulosus biogenic amine 5HT receptor 0.0083 0.0719 0.1726
Echinococcus multilocularis allatostatin A receptor 0.0083 0.0719 0.1726
Loa Loa (eye worm) hypothetical protein 0.0083 0.0719 0.1726
Brugia malayi G protein-coupled receptor F59B2.13 0.0083 0.0719 0.2753
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0083 0.0719 0.1726
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0083 0.0719 0.1726
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0083 0.0719 0.1726
Loa Loa (eye worm) hypothetical protein 0.0083 0.0719 0.1726
Loa Loa (eye worm) hypothetical protein 0.0083 0.0719 0.1726
Loa Loa (eye worm) hypothetical protein 0.0083 0.0719 0.1726
Echinococcus multilocularis somatostatin receptor 0.0083 0.0719 0.1726
Loa Loa (eye worm) hypothetical protein 0.0083 0.0719 0.1726
Onchocerca volvulus 0.0083 0.0719 0.2371
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0083 0.0719 0.0719
Schistosoma mansoni biogenic amine (5HT) receptor 0.0083 0.0719 0.0719
Echinococcus multilocularis neuropeptide Y receptor 0.0083 0.0719 0.1726
Echinococcus multilocularis rhodopsin orphan GPCR 0.0083 0.0719 0.1726
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0083 0.0719 0.1726
Echinococcus granulosus hypothetical protein 0.0083 0.0719 0.1726
Echinococcus granulosus neuropeptide receptor A26 0.0083 0.0719 0.1726
Brugia malayi follicle stimulating hormone receptor 0.0083 0.0719 0.2753
Loa Loa (eye worm) hypothetical protein 0.0083 0.0719 0.1726
Loa Loa (eye worm) hypothetical protein 0.0083 0.0719 0.1726
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0083 0.0719 0.0719
Loa Loa (eye worm) melatonin receptor type 1A 0.0083 0.0719 0.1726
Schistosoma mansoni neuropeptide receptor 0.0083 0.0719 0.0719
Brugia malayi Dopamine receptor protein 2 0.0083 0.0719 0.2753
Loa Loa (eye worm) G-protein coupled receptor 0.0083 0.0719 0.1726
Loa Loa (eye worm) hypothetical protein 0.0083 0.0719 0.1726
Echinococcus granulosus orexin receptor type 2 0.0083 0.0719 0.1726
Onchocerca volvulus 0.0083 0.0719 0.2371
Echinococcus granulosus fmrfamide receptor 0.0083 0.0719 0.1726
Loa Loa (eye worm) hypothetical protein 0.0083 0.0719 0.1726
Echinococcus multilocularis neuropeptide receptor A26 0.0083 0.0719 0.1726
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0083 0.0719 0.1726
Onchocerca volvulus 0.0083 0.0719 0.2371
Loa Loa (eye worm) hypothetical protein 0.0083 0.0719 0.1726
Onchocerca volvulus 0.0083 0.0719 0.2371

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) 0 Growth inhibition of Vibrio harveyi assessed as time required to double bacterial growth relative to control ChEMBL. 18262415
GI50 (functional) = 7.3 uM Antiproliferative activity against human A549 cells after 48 hrs by sulforhodamine B assay ChEMBL. 25752525
IC50 (functional) = 12 uM Antagonist activity at LuxP receptor in Vibrio harveyi MM32 assessed as inhibition of autoinducer2-mediated quorum sensing after 3 to 4 hrs ChEMBL. 18262415
IC50 (functional) = 12 uM Antagonist activity at LuxP receptor in Vibrio harveyi MM32 assessed as inhibition of autoinducer2-mediated quorum sensing after 3 to 4 hrs ChEMBL. 18262415

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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