Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 6.7 ug ml-1 | Minimum inhibitory concentration required to inhibit macroscopic colonial growth of Helicobacter pylori ;ranges from (3.13-12.5) | ChEMBL. | 11754586 |
ND (functional) | 0 | Inhibition of histamine-stimulated gastric acid secretion in lumen-perfused stomach of anesthetized rats after 1 mg/kg iv administration ;ND is No Data. | ChEMBL. | 11754586 |
ND (functional) | 0 | Inhibition of histamine-stimulated chronotropic response in isolated guinea pig right atrium at 1*10e-6 g/mL ;ND is No Data. | ChEMBL. | 11754586 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.