Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0101 | 1 | 1 |
Trypanosoma cruzi | monoglyceride lipase, putative | 0.0069 | 0.641 | 1 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0069 | 0.641 | 0.5 |
Plasmodium vivax | PST-A protein | 0.0069 | 0.641 | 1 |
Plasmodium falciparum | lysophospholipase, putative | 0.0069 | 0.641 | 1 |
Plasmodium falciparum | esterase, putative | 0.0069 | 0.641 | 1 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0101 | 1 | 1 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0101 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0069 | 0.641 | 0.5 |
Chlamydia trachomatis | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.0012 | 0 | 0.5 |
Entamoeba histolytica | hydrolase, alpha/beta fold family domain containing protein | 0.0069 | 0.641 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0069 | 0.641 | 0.5 |
Treponema pallidum | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0012 | 0 | 0.5 |
Plasmodium falciparum | lysophospholipase, putative | 0.0069 | 0.641 | 1 |
Plasmodium falciparum | lysophospholipase, putative | 0.0069 | 0.641 | 1 |
Trypanosoma brucei | monoglyceride lipase, putative | 0.0069 | 0.641 | 1 |
Mycobacterium ulcerans | lysophospholipase | 0.0069 | 0.641 | 1 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0069 | 0.641 | 0.5 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0101 | 1 | 1 |
Leishmania major | monoglyceride lipase, putative | 0.0069 | 0.641 | 1 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0069 | 0.641 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0012 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 1 | 1 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.0101 | 1 | 1 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0069 | 0.641 | 0.5 |
Entamoeba histolytica | hydrolase, alpha/beta fold family domain containing protein | 0.0069 | 0.641 | 0.5 |
Trichomonas vaginalis | valacyclovir hydrolase, putative | 0.0069 | 0.641 | 0.5 |
Mycobacterium leprae | POSSIBLE LYSOPHOSPHOLIPASE | 0.0069 | 0.641 | 1 |
Trypanosoma brucei | monoglyceride lipase, putative | 0.0069 | 0.641 | 1 |
Mycobacterium tuberculosis | Possible lysophospholipase | 0.0069 | 0.641 | 1 |
Schistosoma mansoni | amidase | 0.0101 | 1 | 1 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0069 | 0.641 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0069 | 0.641 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC80 (functional) | = 30 ng/ml | Antifungal activity against Candida albicans CA98001 | ChEMBL. | 18313295 |
MIC80 (functional) | = 30 ng/ml | Antifungal activity against Candida albicans CA98001 | ChEMBL. | 18313295 |
MIC80 (functional) | = 21130 ng/ml | Antifungal activity against Aspergillus fumigatus AF98003 | ChEMBL. | 18313295 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.