Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | isocitrate lyase Icl | 0.0506 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl) | 0.0506 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl) | 0.0506 | 1 | 0.5 |
Mycobacterium tuberculosis | Isocitrate lyase Icl (isocitrase) (isocitratase) | 0.0506 | 1 | 0.5 |
Mycobacterium ulcerans | isocitrate lyase AceAb | 0.0506 | 1 | 0.5 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0298 | 0.2263 | 0.5 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0298 | 0.2263 | 0.5 |
Schistosoma mansoni | lipoxygenase | 0.0298 | 0.2263 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | 0 | Antiinflammatory activity in Escherichia coli lipopolysaccharide-activated rat neonantal microglia assessed as inhibition of oxygen radical at 30 uM | ChEMBL. | 18198837 |
Activity (functional) | 0 | Antiinflammatory activity in Escherichia coli lipopolysaccharide-activated rat neonantal microglia assessed as inhibition of eicosanoid thromboxane B2 at 30 uM | ChEMBL. | 18198837 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.