Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0175 | 0.5892 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0151 | 0.4148 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0232 | 1 | 0.5 |
Trichomonas vaginalis | beta-hexosaminidase, putative | 0.0232 | 1 | 0.5 |
Trichomonas vaginalis | beta-hexosaminidase, putative | 0.0232 | 1 | 0.5 |
Mycobacterium ulcerans | lipoprotein LpqI | 0.0232 | 1 | 0.5 |
Onchocerca volvulus | 0.0101 | 0.0613 | 1 | |
Schistosoma mansoni | alpha-glucosidase | 0.0151 | 0.4148 | 1 |
Mycobacterium tuberculosis | Probable conserved lipoprotein LpqI | 0.0232 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 0.4851 | 0.8233 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0175 | 0.5892 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0175 | 0.5892 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 0.4851 | 0.8233 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0175 | 0.5892 | 1 |
Brugia malayi | Muscleblind-like protein | 0.016 | 0.4851 | 0.8233 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0175 | 0.5892 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Kinact (binding) | = 15 uM | Inhibition of Vibrio cholerae NagZ | ChEMBL. | 17439950 |
Kinact (binding) | = 15 uM | Inhibition of Vibrio cholerae NagZ | ChEMBL. | 17439950 |
Kinact (binding) | = 190 uM | Inhibition of human family 84 O-GLcNAcase | ChEMBL. | 17439950 |
Kinact (binding) | = 190 uM | Inhibition of human family 84 O-GLcNAcase | ChEMBL. | 17439950 |
Kinact (binding) | > 1200 uM | Inhibition of human family 20 beta-hexosaminidase | ChEMBL. | 17439950 |
Selectivity ratio (binding) | = 13 | Ratio of human 84 O-GLcNAcase to Vibrio cholerae NagZ | ChEMBL. | 17439950 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.