Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG12228) | Beta-hexosaminidase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Trichomonas vaginalis | conserved hypothetical protein | Get druggable targets OG5_130549 | All targets in OG5_130549 |
Trichomonas vaginalis | beta-hexosaminidase, putative | Get druggable targets OG5_130549 | All targets in OG5_130549 |
Trichomonas vaginalis | beta-hexosaminidase, putative | Get druggable targets OG5_130549 | All targets in OG5_130549 |
Mycobacterium ulcerans | lipoprotein LpqI | Get druggable targets OG5_130549 | All targets in OG5_130549 |
Mycobacterium tuberculosis | Probable conserved lipoprotein LpqI | Get druggable targets OG5_130549 | All targets in OG5_130549 |
Mycobacterium leprae | PROBABLE CONSERVED LIPOPROTEIN LPQI | Get druggable targets OG5_130549 | All targets in OG5_130549 |
Candida albicans | potential glucosidase similar to bacterial beta-glucosidases | Get druggable targets OG5_130549 | All targets in OG5_130549 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0175 | 0.5892 | 1 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0175 | 0.5892 | 1 |
Brugia malayi | Muscleblind-like protein | 0.016 | 0.4851 | 0.8233 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 0.4851 | 0.8233 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0175 | 0.5892 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0175 | 0.5892 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 0.4851 | 0.8233 |
Schistosoma mansoni | alpha-glucosidase | 0.0151 | 0.4148 | 1 |
Mycobacterium tuberculosis | Probable conserved lipoprotein LpqI | 0.0232 | 1 | 0.5 |
Schistosoma mansoni | alpha-glucosidase | 0.0151 | 0.4148 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0232 | 1 | 0.5 |
Trichomonas vaginalis | beta-hexosaminidase, putative | 0.0232 | 1 | 0.5 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0175 | 0.5892 | 1 |
Onchocerca volvulus | 0.0101 | 0.0613 | 1 | |
Trichomonas vaginalis | beta-hexosaminidase, putative | 0.0232 | 1 | 0.5 |
Mycobacterium ulcerans | lipoprotein LpqI | 0.0232 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 3.5 uM | Inhibition of Pseudomonas aeruginosa PAO1 nagZ gene after 1.5 hrs by fluorescence spectrophotometry | ChEMBL. | 19273679 |
Kinact (binding) | = 3.1 uM | Inhibition of Vibrio cholerae NagZ | ChEMBL. | 17439950 |
Kinact (binding) | = 3.1 uM | Inhibition of Vibrio cholerae NagZ | ChEMBL. | 17439950 |
Kinact (binding) | = 337 uM | Inhibition of human family 84 O-GLcNAcase | ChEMBL. | 17439950 |
Kinact (binding) | = 337 uM | Inhibition of human family 84 O-GLcNAcase | ChEMBL. | 17439950 |
Kinact (binding) | > 3000 uM | Inhibition of human family 20 beta-hexosaminidase | ChEMBL. | 17439950 |
Selectivity ratio (binding) | = 100 | Selectivity for Vibrio cholerae NagZ over human family 20 beta-hexosaminidase | ChEMBL. | 17439950 |
Selectivity ratio (binding) | = 100 | Selectivity for Vibrio cholerae NagZ over human family 84 O-GLcNAcas | ChEMBL. | 17439950 |
Selectivity ratio (binding) | = 109 | Ratio of human 84 O-GLcNAcase to Vibrio cholerae NagZ | ChEMBL. | 17439950 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.