Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | conserved hypothetical protein | 0.0232 | 1 | 0.5 |
Schistosoma mansoni | alpha-glucosidase | 0.0151 | 0.4148 | 1 |
Trichomonas vaginalis | beta-hexosaminidase, putative | 0.0232 | 1 | 0.5 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0175 | 0.5892 | 1 |
Onchocerca volvulus | 0.0101 | 0.0613 | 1 | |
Trichomonas vaginalis | beta-hexosaminidase, putative | 0.0232 | 1 | 0.5 |
Mycobacterium ulcerans | lipoprotein LpqI | 0.0232 | 1 | 0.5 |
Schistosoma mansoni | alpha-glucosidase | 0.0151 | 0.4148 | 1 |
Mycobacterium tuberculosis | Probable conserved lipoprotein LpqI | 0.0232 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 0.4851 | 0.8233 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0175 | 0.5892 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 0.4851 | 0.8233 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0175 | 0.5892 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0175 | 0.5892 | 1 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0175 | 0.5892 | 1 |
Brugia malayi | Muscleblind-like protein | 0.016 | 0.4851 | 0.8233 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Kinact (binding) | = 0.26 uM | Inhibition of Vibrio cholerae NagZ | ChEMBL. | 17439950 |
Kinact (binding) | = 0.26 uM | Inhibition of Vibrio cholerae NagZ | ChEMBL. | 17439950 |
Kinact (binding) | = 26 uM | Inhibition of human family 20 beta-hexosaminidase | ChEMBL. | 17439950 |
Kinact (binding) | = 40 uM | Inhibition of human family 84 O-GLcNAcase | ChEMBL. | 17439950 |
Kinact (binding) | = 40 uM | Inhibition of human family 84 O-GLcNAcase | ChEMBL. | 17439950 |
Selectivity ratio (binding) | = 9.6 | Ratio of human 84 O-GLcNAcase to Vibrio cholerae NagZ | ChEMBL. | 17439950 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.