Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cholinergic receptor, muscarinic 4 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Prolyl endopeptidase homolog | 0.073 | 1 | 0.5 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.029 | 0 | 0.5 |
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.073 | 1 | 1 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.029 | 0 | 0.5 |
Trypanosoma brucei | prolyl endopeptidase | 0.073 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.073 | 1 | 0.5 |
Echinococcus granulosus | prolyl endopeptidase | 0.073 | 1 | 0.5 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.073 | 1 | 0.5 |
Toxoplasma gondii | prolyl endopeptidase | 0.073 | 1 | 0.5 |
Echinococcus multilocularis | prolyl endopeptidase | 0.073 | 1 | 0.5 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.073 | 1 | 0.5 |
Trypanosoma cruzi | prolyl endopeptidase | 0.073 | 1 | 1 |
Mycobacterium tuberculosis | Probable protease II PtrBa [first part] (oligopeptidase B) | 0.0653 | 0.8259 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = -5.57 | Displacement of [3H]N-methylscopolamine from human muscarinic M4 receptor expressed in CHO-K1 cells | ChEMBL. | 18395442 |
Ki (binding) | = -4.59 | Displacement of [3H]N-methylscopolamine from human muscarinic M5 receptor expressed in CHO-K1 cells | ChEMBL. | 18395442 |
Ki (binding) | = 5.08 | Displacement of [3H]N-methylscopolamine from human muscarinic M1 receptor expressed in CHO-K1 cells | ChEMBL. | 18395442 |
Ki (binding) | = 5.36 | Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells | ChEMBL. | 18395442 |
Ki (binding) | = 5.44 | Displacement of [3H]N-methylscopolamine from human muscarinic M3 receptor expressed in CHO-K1 cells | ChEMBL. | 18395442 |
Log Ki (binding) | = 4.59 | Displacement of [3H]N-methylscopolamine from human muscarinic M5 receptor expressed in CHO-K1 cells | ChEMBL. | 18395442 |
Log Ki (binding) | = 5.08 | Displacement of [3H]N-methylscopolamine from human muscarinic M1 receptor expressed in CHO-K1 cells | ChEMBL. | 18395442 |
Log Ki (binding) | = 5.36 | Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells | ChEMBL. | 18395442 |
Log Ki (binding) | = 5.44 | Displacement of [3H]N-methylscopolamine from human muscarinic M3 receptor expressed in CHO-K1 cells | ChEMBL. | 18395442 |
Log Ki (binding) | = 5.57 | Displacement of [3H]N-methylscopolamine from human muscarinic M4 receptor expressed in CHO-K1 cells | ChEMBL. | 18395442 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.