Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | hydroxysteroid 11-beta dehydrogenase 1 | Starlite/ChEMBL | References |
Homo sapiens | hydroxysteroid (11-beta) dehydrogenase 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium ulcerans | short chain dehydrogenase | Get druggable targets OG5_132866 | All targets in OG5_132866 |
Mycobacterium tuberculosis | Probable oxidoreductase | Get druggable targets OG5_132866 | All targets in OG5_132866 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | steroid dehydrogenase, putative | hydroxysteroid (11-beta) dehydrogenase 1 | 292 aa | 250 aa | 24.8 % |
Plasmodium falciparum | steroid dehydrogenase, putative | hydroxysteroid 11-beta dehydrogenase 1 | 292 aa | 246 aa | 25.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | cytochrome c | 0.0032 | 0 | 0.5 |
Leishmania major | telomerase reverse transcriptase, putative | 0.046 | 0.2591 | 1 |
Plasmodium vivax | telomerase reverse transcriptase, putative | 0.046 | 0.2591 | 1 |
Plasmodium falciparum | telomerase reverse transcriptase | 0.046 | 0.2591 | 1 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0676 | 0.3898 | 0.5 |
Echinococcus granulosus | cytochrome c | 0.0032 | 0 | 0.5 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.046 | 0.2591 | 1 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.046 | 0.2591 | 1 |
Giardia lamblia | Telomerase catalytic subunit | 0.046 | 0.2591 | 0.5 |
Echinococcus multilocularis | cytochrome c | 0.0032 | 0 | 0.5 |
Brugia malayi | Telomerase reverse transcriptase | 0.1224 | 0.7216 | 1 |
Wolbachia endosymbiont of Brugia malayi | cytochrome c2 | 0.0032 | 0 | 0.5 |
Toxoplasma gondii | RNA-directed DNA polymerase | 0.046 | 0.2591 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0676 | 0.3898 | 0.5 |
Trypanosoma brucei | telomerase reverse transcriptase | 0.046 | 0.2591 | 1 |
Loa Loa (eye worm) | cytochrome c type-1 | 0.0032 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 7.7 nM | Inhibition of human 11beta-HSD1 expressed in CHO-K1 cells | ChEMBL. | 18434143 |
IC50 (binding) | = 7.7 nM | Inhibition of human 11beta-HSD1 expressed in CHO-K1 cells | ChEMBL. | 18434143 |
IC50 (binding) | = 10 nM | Inhibition of mouse 11beta-HSD1 expressed in CHO-K1 cells | ChEMBL. | 18434143 |
IC50 (binding) | = 10 nM | Inhibition of mouse 11beta-HSD1 expressed in CHO-K1 cells | ChEMBL. | 18434143 |
Inhibition (functional) | = 3 % | Inhibition of mouse 11beta-HSD2 mediated [3H]cortisone to [3H]cortisol conversion at 10 mg/kg, po after 16 hrs | ChEMBL. | 18434143 |
Inhibition (functional) | = 3 % | Inhibition of mouse 11beta-HSD2 mediated [3H]cortisone to [3H]cortisol conversion at 10 mg/kg, po after 16 hrs | ChEMBL. | 18434143 |
Inhibition (functional) | = 38 % | Inhibition of mouse 11beta-HSD2 mediated [3H]cortisone to [3H]cortisol conversion at 10 mg/kg, po after 4 hrs | ChEMBL. | 18434143 |
Inhibition (functional) | = 38 % | Inhibition of mouse 11beta-HSD2 mediated [3H]cortisone to [3H]cortisol conversion at 10 mg/kg, po after 4 hrs | ChEMBL. | 18434143 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.