Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | Starlite/ChEMBL | References |
Homo sapiens | progesterone receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | ecdysone induced protein 78C | 0.0018 | 0.5 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0018 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0018 | 0.5 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0018 | 0.5 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0018 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0018 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0018 | 0.5 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0018 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0018 | 0.5 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0018 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0018 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0018 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0018 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0018 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0018 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0018 | 0.5 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0018 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0018 | 0.5 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0018 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0018 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0018 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0018 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0018 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0018 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0018 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0018 | 0.5 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0018 | 0.5 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0018 | 0.5 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0018 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0018 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0018 | 0.5 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0018 | 0.5 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0018 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0018 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0018 | 0.5 | 0.5 | |
Onchocerca volvulus | Bile acid receptor homolog | 0.0018 | 0.5 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0018 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.5 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0018 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0018 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0018 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0018 | 0.5 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0018 | 0.5 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0018 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0018 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0018 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0018 | 0.5 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0018 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0018 | 0.5 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0018 | 0.5 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0018 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0018 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0018 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0018 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0018 | 0.5 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0018 | 0.5 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0018 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0018 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0018 | 0.5 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0018 | 0.5 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0018 | 0.5 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0018 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.5 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0018 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 433 nM | Agonist activity at glucocorticoid receptor (unknown origin) assessed as glucose repsponse element transcriptional transactivation by luciferase assay | ChEMBL. | 18513967 |
EC50 (functional) | = 433 nM | Agonist activity at glucocorticoid receptor (unknown origin) assessed as glucose repsponse element transcriptional transactivation by luciferase assay | ChEMBL. | 18513967 |
Efficacy (binding) | < 20 % | Activity at glucocorticoid receptor (unknown origin) assessed as repression of TNFalpha and IL1 beta-induced E-selectin expression relative to prednislone | ChEMBL. | 18513967 |
Efficacy (binding) | < 20 % | Activity at glucocorticoid receptor (unknown origin) assessed as repression of TNFalpha and IL1 beta-induced E-selectin expression relative to prednislone | ChEMBL. | 18513967 |
Efficacy (functional) | = 34 % | Agonist activity at glucocorticoid receptor (unknown origin) assessed as glucose repsponse element transcriptional transactivation by luciferase assay relative to dexamethasone | ChEMBL. | 18513967 |
Efficacy (functional) | = 34 % | Agonist activity at glucocorticoid receptor (unknown origin) assessed as glucose repsponse element transcriptional transactivation by luciferase assay relative to dexamethasone | ChEMBL. | 18513967 |
Efficacy (functional) | = 62 % | Antagonist activity at glucocorticoid receptor (unknown origin) assessed as inhibition of dexamethasone-induced glucose response element transcriptional transactivation by luciferase assay relative to control | ChEMBL. | 18513967 |
Efficacy (functional) | = 62 % | Antagonist activity at glucocorticoid receptor (unknown origin) assessed as inhibition of dexamethasone-induced glucose response element transcriptional transactivation by luciferase assay relative to control | ChEMBL. | 18513967 |
IC50 (functional) | = 1.8 nM | Antagonist activity at glucocorticoid receptor (unknown origin) assessed as inhibition of dexamethasone-induced glucose response element transcriptional transactivation by luciferase assay | ChEMBL. | 18513967 |
IC50 (functional) | = 1.8 nM | Antagonist activity at glucocorticoid receptor (unknown origin) assessed as inhibition of dexamethasone-induced glucose response element transcriptional transactivation by luciferase assay | ChEMBL. | 18513967 |
IC50 (binding) | > 1 uM | Activity at glucocorticoid receptor (unknown origin) assessed as repression of TNFalpha and IL1 beta-induced E-selectin expression | ChEMBL. | 18513967 |
IC50 (binding) | > 1 uM | Activity at glucocorticoid receptor (unknown origin) assessed as repression of TNFalpha and IL1 beta-induced E-selectin expression | ChEMBL. | 18513967 |
Ki (binding) | = 4.4 nM | Displacement of radiolabeled dexamethasone from glucocorticoid receptor (unknown origin) | ChEMBL. | 18513967 |
Ki (binding) | = 4.4 nM | Displacement of radiolabeled dexamethasone from glucocorticoid receptor (unknown origin) | ChEMBL. | 18513967 |
Ki (binding) | = 230 nM | Binding affinity at progesterone receptor (unknown origin) | ChEMBL. | 18513967 |
Ki (binding) | = 230 nM | Binding affinity at progesterone receptor (unknown origin) | ChEMBL. | 18513967 |
Selectivity ratio (binding) | > 40 | Selectivity of glucocorticoid receptor (unknown origin) over progesterone receptor (unknown origin) | ChEMBL. | 18513967 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.