Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
A50 (binding) | = 0.000002 M | Displacement of [3H]-E2 specific binding to estrogen receptor | ChEMBL. | 2995668 |
A50 (binding) | = 0.000002 M | Displacement of [3H]-E2 specific binding to estrogen receptor | ChEMBL. | 2995668 |
Effect (functional) | = 76 % | Percent uterotrophic effect at 500 ug/day dose compared to estradiol | ChEMBL. | 2995668 |
Effect (functional) | = 76 % | Percent uterotrophic effect at 500 ug/day dose compared to estradiol | ChEMBL. | 2995668 |
KA | = 0.0000000019 M | Dissociation constant of the compound was evaluated. | ChEMBL. | 2995668 |
Max uterine weight (functional) | = 54 mg | Uterotrophic effect in rats uterine at 500 ug/day dose | ChEMBL. | 2995668 |
Max uterine weight (functional) | = 54 mg | Uterotrophic effect in rats uterine at 500 ug/day dose | ChEMBL. | 2995668 |
Uterine weight (functional) | = 29.6 | Uterotrophic effect in rats uterine at 1 ug/day dose | ChEMBL. | 2995668 |
Uterine weight (functional) | = 43 | Uterotrophic effect in rats uterine at 100 ug/day dose in the presence of 0.20 ug estradiol | ChEMBL. | 2995668 |
Uterine weight (functional) | = 44 | Uterotrophic effect in rats uterine at 10 ug/day dose | ChEMBL. | 2995668 |
Uterine weight (functional) | = 46 | Uterotrophic effect in rats uterine at 500 ug/day dose in the presence of 0.10 ug estradiol | ChEMBL. | 2995668 |
Uterine weight (functional) | = 46 | Uterotrophic effect in rats uterine at 100 ug/day dose in the presence of 0.05 ug hexestrol | ChEMBL. | 2995668 |
Uterine weight (functional) | = 50.3 | Uterotrophic effect in rats uterine at 100 ug/day dose | ChEMBL. | 2995668 |
Uterine weight (functional) | = 54 | Uterotrophic effect in rats uterine at 500 ug/day dose | ChEMBL. | 2995668 |
Uterine weight (functional) | = 54.8 | Uterotrophic effect in rats uterine at 10 ug/day dosein the presence of 0.08 ug estradiol | ChEMBL. | 2995668 |
Uterine weight (functional) | = 56.5 | Uterotrophic effect in rats uterine at 500 ug/day dose in the presence of 0.08 ug estradiol | ChEMBL. | 2995668 |
Uterine weight (functional) | = 57.1 | Uterotrophic effect in rats uterine at 100 ug/day dose in the presence of 10 ug estradiol | ChEMBL. | 2995668 |
Uterine weight (functional) | = 58.2 | Uterotrophic effect in rats uterine at 1 ug/day dose in the presence of 0.08 ug estradiol | ChEMBL. | 2995668 |
Uterine weight (functional) | = 62 | Uterotrophic effect in rats uterine at 500 ug/day dose in the presence of 0.2 ug estradiol | ChEMBL. | 2995668 |
Uterine weight (functional) | = 67.2 | Uterotrophic effect in rats uterine at 500 ug/day dose in the presence of 10 ug estradiol | ChEMBL. | 2995668 |
Uterine weight (functional) | = 70.3 | Uterotrophic effect in rats uterine at 100 ug/day dose in the presence of 0.05 ug hexestrol | ChEMBL. | 2995668 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.