Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0594 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0594 | 0.5 | 0.5 |
Loa Loa (eye worm) | NNMT/PNMT/TEMT family protein | 0.0594 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (functional) | > 100 uM | Cytotoxicity in uninfected CEM cells | ChEMBL. | 12672254 |
CC50 (functional) | > 100 uM | Cytotoxicity in uninfected CEM cells | ChEMBL. | 12672254 |
CC50 (functional) | > 181 uM | Cytotoxicity in uninfected Daudi cells | ChEMBL. | 12672254 |
CC50 (functional) | > 181 uM | Cytotoxicity in uninfected Daudi cells | ChEMBL. | 12672254 |
CC50 (functional) | > 362 uM | Cytotoxicity in uninfected MEF cells | ChEMBL. | 12672254 |
CC50 (functional) | > 362 uM | Cytotoxicity in uninfected MEF cells | ChEMBL. | 12672254 |
Cytotoxicity (functional) | = 39 | Visual cytotoxicity was scored on uninfected HFF cells not affected by virus in the HCMV (Towne strain) plaque reduction assay | ChEMBL. | 12672254 |
Cytotoxicity (functional) | > 72 | Cytotoxicity was scored on uninfected HFF cells not affected by virus in the HCMV (AD169 strain) by neutral red uptake | ChEMBL. | 12672254 |
Cytotoxicity (functional) | > 362 | Cytotoxicity was scored on uninfected HFF cells not affected by virus in the HCMV (AD169 strain) by neutral red uptake | ChEMBL. | 12672254 |
EC50 (functional) | = 11.9 uM | Concentration inhibiting the replication of MCMV in MEF cells | ChEMBL. | 12672254 |
EC50 (functional) | > 20 uM | Concentration inhibiting the replication of EBV in H-1 cells by DNA hybridization assay | ChEMBL. | 12672254 |
EC50 (functional) | > 20 uM | Inhibition of the replication of HBV in 2.2.15 cells, by DNA hybridization assay | ChEMBL. | 12672254 |
EC50 (functional) | > 50 uM | Concentration inhibiting the replication of HSV-1 in Vero cells determined by plaque reduction assay | ChEMBL. | 12672254 |
EC50 (functional) | > 50 uM | Concentration inhibiting the replication of HSV-2 in Vero cells. | ChEMBL. | 12672254 |
EC50 (functional) | > 60 uM | Concentration inhibiting the replication of HBV in HFF cells by plaque reduction assay | ChEMBL. | 12672254 |
EC50 (functional) | > 100 uM | Concentration inhibiting the replication of HSV-1 in BSC-1 cells determined by ELISA assay | ChEMBL. | 12672254 |
EC50 (functional) | > 181 uM | Concentration inhibiting the replication of EBV in Daudi cells | ChEMBL. | 12672254 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.