Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | dgat2l1-prov protein | 0.0079 | 0 | 0.5 |
Trypanosoma brucei | diacylglycerol acyltransferase, putative | 0.0079 | 0 | 0.5 |
Trypanosoma cruzi | diacylglycerol acyltransferase, putative | 0.0079 | 0 | 0.5 |
Trypanosoma cruzi | diacylglycerol acyltransferase, putative | 0.0079 | 0 | 0.5 |
Schistosoma mansoni | diacylglycerol O-acyltransferase 1 | 0.0079 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1445 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1445 | 1 | 1 |
Onchocerca volvulus | 0.0079 | 0 | 0.5 | |
Loa Loa (eye worm) | NNMT/PNMT/TEMT family protein | 0.1445 | 1 | 1 |
Leishmania major | diacylglycerol acyltransferase, putative | 0.0079 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 16 nM | Vasorelaxant potency in isolated potassium (K+)-depolarized rabbit thoracic aorta. | ChEMBL. | 2329573 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.