Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | protein kinase, putative | 0.0088 | 1 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0088 | 1 | 0.5 |
Trichomonas vaginalis | serine threonine-protein kinase, putative | 0.0045 | 0.1702 | 0.5 |
Echinococcus granulosus | serine:threonine protein kinase:endoribonuclease | 0.0088 | 1 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0045 | 0.1702 | 0.5 |
Loa Loa (eye worm) | IRE protein kinase | 0.0088 | 1 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase:endoribonuclease | 0.0088 | 1 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0045 | 0.1755 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | 0 | Inhibition of Renilla reniformis luciferase | ChEMBL. | 18363348 |
IC50 (binding) | = 0.15 uM | Inhibition of Photinus pyralis luciferase | ChEMBL. | 18363348 |
IC50 (binding) | = 0.3 uM | Inhibition of Photinus pyralis luciferase by BrightGlo reporter gene assay | ChEMBL. | 18363348 |
IC50 (binding) | = 0.4 uM | Inhibition of Photinus pyralis luciferase by PK-Light assay | ChEMBL. | 18363348 |
IC50 (binding) | = 1.1 uM | Inhibition of Photinus pyralis luciferase by Easy lite assay | ChEMBL. | 18363348 |
IC50 (binding) | = 1.1 uM | Inhibition of Photinus pyralis luciferase by Steady-Glo reporter gene assay | ChEMBL. | 18363348 |
IC50 (binding) | = 13 uM | Inhibition of luciferase Photuris pennsylvanica by Promega Kinase-Glo assay | ChEMBL. | 18363348 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.