Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | retinoic acid receptor RXR | 0.0115 | 1 | 1 |
Schistosoma mansoni | jun-related protein | 0.0069 | 0.4171 | 0.4171 |
Echinococcus granulosus | jun protein | 0.0085 | 0.6186 | 0.6186 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.5891 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0 | 0.5 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0107 | 0.8974 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0085 | 0.6186 | 0.6894 |
Schistosoma mansoni | hypothetical protein | 0.0069 | 0.4171 | 0.4171 |
Brugia malayi | bZIP transcription factor family protein | 0.0085 | 0.6186 | 1 |
Echinococcus multilocularis | jun protein | 0.0085 | 0.6186 | 0.6894 |
Onchocerca volvulus | 0.0067 | 0.3876 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0067 | 0.3876 | 0.6265 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0085 | 0.6186 | 0.6186 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 14 % | Cell cycle arrest in human K562 cells assessed as accumulation at G2/M phase at 10 uM after 24 hrs by flow cytometry | ChEMBL. | 18293907 |
Activity (functional) | = 14 % | Cell cycle arrest in human K562 cells assessed as accumulation at G2/M phase at 10 uM after 24 hrs by flow cytometry | ChEMBL. | 18293907 |
Inhibition (binding) | = 1.3 % | Inhibition of ABCG2-mediated mitoxantrone efflux expressed in HEK293 cells at 2 uM after 48 hrs by flow cytometric analysis | ChEMBL. | 22449016 |
Inhibition (binding) | = 17.4 % | Inhibition of ABCG2-mediated mitoxantrone efflux expressed in HEK293 cells at 10 uM after 48 hrs by flow cytometric analysis | ChEMBL. | 22449016 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.