Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Malate synthase G GlcB | 0.236 | 1 | 1 |
Mycobacterium ulcerans | malate synthase G | 0.236 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 23 % | Cell cycle arrest in human K562 cells assessed as accumulation at G2/M phase at 10 uM after 24 hrs by flow cytometry | ChEMBL. | 18293907 |
Activity (functional) | = 23 % | Cell cycle arrest in human K562 cells assessed as accumulation at G2/M phase at 10 uM after 24 hrs by flow cytometry | ChEMBL. | 18293907 |
Activity (functional) | = 105 % | Increase in intracellular GSH level in human MCF7 cells expressing antioxidant response element at 10 uM after 6 hrs by HPLC analysis relative to control | ChEMBL. | 22239485 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.