Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Trypanosoma cruzi | squalene synthase, putative | Curated by TDR Targets | No references |
Homo sapiens | farnesyl-diphosphate farnesyltransferase 1 | Starlite/ChEMBL | References |
Trypanosoma cruzi | squalene synthase, putative | Curated by TDR Targets | No references |
Leishmania major | squalene synthase, putative | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | squalene synthase, putative | 0.0591204 | 0.5 | 0.5 |
Trypanosoma cruzi | squalene synthase, putative | 0.0591204 | 0.5 | 0.5 |
Trypanosoma cruzi | squalene synthase, putative | 0.0591204 | 0.5 | 0.5 |
Leishmania major | squalene synthase, putative | 0.0591204 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (ADMET) | 0 | Growth inhibition of rat L6 cells | ChEMBL. | 17371809 |
IC50 (binding) | = 0.00084 uM | Inhibition of Trypanosoma cruzi recombinant squalene synthase | ChEMBL. | 17371809 |
IC50 (binding) | = 0.0015 uM | Inhibition of human recombinant squalene synthase | ChEMBL. | 17371809 |
IC50 (binding) | = 0.0015 uM | Inhibition of human recombinant squalene synthase | ChEMBL. | 17371809 |
IC50 (functional) | = 0.008 uM | Antitrypanosomal activity against intracellular Trypanosoma cruzi amastigotes in rat L6 cells | ChEMBL. | 17371809 |
IC50 (functional) | = 0.008 uM | Antitrypanosomal activity against intracellular Trypanosoma cruzi amastigotes in rat L6 cells | ChEMBL. | 17371809 |
IC50 (binding) | = 0.013 uM | Inhibition of Leishmania major recombinant squalene synthase expressed in Escherichia coli by liquid scintillation counter | ChEMBL. | 17709461 |
Ratio IC50 (binding) | = 1.8 | Selectivity index, ratio of IC50 for human recombinat squalene synthase over IC50 for Trypanosoma cruzi squalene synthase | ChEMBL. | 17371809 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Trypanosoma cruzi | ChEMBL23 | 17371809 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.