Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0124 | 0.5175 | 0.3524 |
Schistosoma mansoni | thyroid hormone receptor | 0.0142 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0142 | 1 | 1 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0124 | 0.5175 | 0.5175 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0124 | 0.5175 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Antileishmanial activity against Leishmania major MHOM/IL/81/FE/BNI amastigotes after 48 hrs at 1 uM | ChEMBL. | 17371810 | |
Activity (functional) | Antimicrobial activity against Schistosoma mansoni assessed as worm vitality at 1 uM after 4 hrs | ChEMBL. | 17371810 | |
Activity (functional) | Antimicrobial activity against Schistosoma mansoni assessed as worm vitality at 6 uM after 4 hrs | ChEMBL. | 17371810 | |
Activity (functional) | Antimicrobial activity against Schistosoma mansoni assessed as worm vitality at 3 uM after 4 hrs | ChEMBL. | 17371810 | |
Activity (functional) | 0 | Antimicrobial activity against Schistosoma mansoni assessed as worm vitality at 1 uM after 4 hrs | ChEMBL. | 17371810 |
Activity (functional) | 0 | Antimicrobial activity against Schistosoma mansoni assessed as worm vitality at 3 uM after 4 hrs | ChEMBL. | 17371810 |
Activity (functional) | 0 | Antimicrobial activity against Schistosoma mansoni assessed as worm vitality at 6 uM after 4 hrs | ChEMBL. | 17371810 |
Activity (functional) | 0 | Antileishmanial activity against Leishmania major MHOM/IL/81/FE/BNI amastigotes after 48 hrs at 1 uM | ChEMBL. | 17371810 |
Activity (ADMET) | 0 | Cytotoxicity against BALB/c mouse peritoneal macrophages at 10 uM after 48 hrs hrs | ChEMBL. | 17371810 |
Activity (functional) | = 42 % | Antileishmanial activity against Leishmania donovani MHOM/SD/00/1S-2D promastigotes assessed as parasite death at 10 uM after 72 hrs | ChEMBL. | 17371810 |
Activity (functional) | = 42 % | Antileishmanial activity against Leishmania donovani MHOM/SD/00/1S-2D promastigotes assessed as parasite death at 10 uM after 72 hrs | ChEMBL. | 17371810 |
Activity (functional) | = 59 % | Antimicrobial activity against Trichomonas vaginalis G3 assessed as parasite death at 10 uM after 24 hrs | ChEMBL. | 17371810 |
Activity (functional) | = 59 % | Antimicrobial activity against Trichomonas vaginalis G3 assessed as parasite death at 10 uM after 24 hrs | ChEMBL. | 17371810 |
EC50 (functional) | = 31 nM | Antimicrobial activity against Trypanosoma brucei brucei clone 427-221a after 48 hrs | ChEMBL. | 17371810 |
EC50 (functional) | = 31 nM | Antimicrobial activity against Trypanosoma brucei brucei clone 427-221a after 48 hrs | ChEMBL. | 17371810 |
EC50 (functional) | = 62 nM | Antimicrobial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 72 hrs | ChEMBL. | 17371810 |
EC50 (functional) | = 62 nM | Antimicrobial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 72 hrs | ChEMBL. | 17371810 |
EC50 (functional) | = 69 nM | Antimicrobial activity against chloroquine-resistant Plasmodium falciparum W2 after 72 hrs | ChEMBL. | 17371810 |
EC50 (functional) | = 69 nM | Antimicrobial activity against chloroquine-resistant Plasmodium falciparum W2 after 72 hrs | ChEMBL. | 17371810 |
EC50 (ADMET) | = 26300 nM | Cytotoxicity against human HL60 cells | ChEMBL. | 17371810 |
EC50 (ADMET) | = 26300 nM | Cytotoxicity against human HL60 cells | ChEMBL. | 17371810 |
EC50 (functional) | = 5 uM | Antimicrobial activity against Entamoeba histolytica HM1 IMSS tropozoits after 48 hrs | ChEMBL. | 17371810 |
EC50 (functional) | = 5 uM | Antimicrobial activity against Entamoeba histolytica HM1 IMSS tropozoits after 48 hrs | ChEMBL. | 17371810 |
MIC (functional) | = 1000 nM | Antimicrobial activity against Trypanosoma brucei brucei clone 427-221a after 48 hrs | ChEMBL. | 17371810 |
MIC (functional) | = 1000 nM | Antimicrobial activity against Trypanosoma brucei brucei clone 427-221a after 48 hrs | ChEMBL. | 17371810 |
MIC (ADMET) | > 10000 nM | Cytotoxicity against human HL60 cells | ChEMBL. | 17371810 |
MIC (ADMET) | > 10000 nM | Cytotoxicity against human HL60 cells | ChEMBL. | 17371810 |
Ratio (functional) | > 10 | Selectivity index, ratio of MIC for HL60 cells to MIC for Trypanosoma brucei brucei clone 427-221a | ChEMBL. | 17371810 |
Ratio EC50 (functional) | = 859 | Selectivity index, ratio of EC50 for HL60 cells to EC50 for Trypanosoma brucei brucei clone 427-221a | ChEMBL. | 17371810 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 17371810 | |
Entamoeba histolytica | ChEMBL23 | 17371810 | |
Trypanosoma brucei gambiense | 17371810 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.