Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.001 | 0 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.001 | 0 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.001 | 0 | 0.5 |
Loa Loa (eye worm) | tyrosinase 1 | 0.0089 | 1 | 1 |
Brugia malayi | Common central domain of tyrosinase family protein | 0.0089 | 1 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.001 | 0 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.001 | 0 | 0.5 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0089 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.001 | 0 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.001 | 0 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.001 | 0 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.001 | 0 | 0.5 |
Onchocerca volvulus | 0.0089 | 1 | 1 | |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.001 | 0 | 0.5 |
Loa Loa (eye worm) | ShTK domain-containing protein | 0.0089 | 1 | 1 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0089 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.001 | 0 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.001 | 0 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.001 | 0 | 0.5 |
Brugia malayi | Hypothetical tyrosinase-like protein F21C3.2 in chromosome I | 0.0089 | 1 | 1 |
Onchocerca volvulus | 0.0089 | 1 | 1 | |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.001 | 0 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.001 | 0 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.001 | 0 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.001 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 1 | 1 |
Onchocerca volvulus | 0.0089 | 1 | 1 | |
Onchocerca volvulus | 0.0089 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 1 | 1 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0089 | 1 | 1 |
Loa Loa (eye worm) | ShTK domain-containing protein | 0.0089 | 1 | 1 |
Schistosoma mansoni | tyrosinase precursor | 0.0089 | 1 | 1 |
Schistosoma mansoni | tyrosinase precursor | 0.0089 | 1 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.001 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 15 uM | Antifungal activity against Saccharomyces cerevisiae W303-1B after 48 hrs by broth microdilution assay | ChEMBL. | 18180161 |
MIC (functional) | = 15 uM | Antifungal activity against Saccharomyces cerevisiae W303-1B after 48 hrs by broth microdilution assay | ChEMBL. | 18180161 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.