Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0.0351 | 0.5 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.004 | 0.0889 | 0.4275 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0036 | 0.0774 | 1 |
Schistosoma mansoni | inositol monophosphatase | 0.004 | 0.0889 | 0.5384 |
Onchocerca volvulus | 0.0066 | 0.1588 | 1 | |
Loa Loa (eye worm) | inositol-1 | 0.004 | 0.0889 | 0.4408 |
Brugia malayi | Inositol-1 | 0.004 | 0.0889 | 0.4275 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.2017 | 1 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.004 | 0.0889 | 1 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0021 | 0.0351 | 0.169 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.004 | 0.0889 | 1 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.004 | 0.0889 | 0.4275 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.004 | 0.0889 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 0.0351 | 0.2128 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0021 | 0.0351 | 0.169 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0085 | 0.2079 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0085 | 0.2079 | 1 |
Schistosoma mansoni | jun-related protein | 0.0069 | 0.1651 | 1 |
Echinococcus granulosus | jun protein | 0.0085 | 0.2079 | 1 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.004 | 0.0889 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0069 | 0.1651 | 1 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.004 | 0.0889 | 1 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0036 | 0.0774 | 0.5 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.004 | 0.0889 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 0.0351 | 0.2128 |
Echinococcus multilocularis | jun protein | 0.0085 | 0.2079 | 1 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0021 | 0.0351 | 0.1742 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.004 | 0.0889 | 1 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.004 | 0.0889 | 1 |
Brugia malayi | hypothetical protein | 0.0066 | 0.1588 | 0.7639 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0.0351 | 0.5 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0021 | 0.0351 | 0.169 |
Chlamydia trachomatis | 2-dehydro-3-deoxyphosphooctonate aldolase | 0.0377 | 1 | 0.5 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.004 | 0.0889 | 1 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.004 | 0.0889 | 1 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.004 | 0.0889 | 1 |
Brugia malayi | bZIP transcription factor family protein | 0.0085 | 0.2079 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0021 | 0.0351 | 0.5 |
Schistosoma mansoni | inositol monophosphatase | 0.004 | 0.0889 | 0.5384 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0021 | 0.0351 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | = 82.7 uM | Antiproliferative activity against human HT29 cells after 48 hrs | ChEMBL. | 17998163 |
GI50 (functional) | = 82.7 uM | Antiproliferative activity against human HT29 cells after 48 hrs | ChEMBL. | 17998163 |
GI50 (functional) | > 100 uM | Antiproliferative activity against human M21 cells after 48 hrs | ChEMBL. | 17998163 |
GI50 (functional) | > 100 uM | Antiproliferative activity against human MCF7 cells after 48 hrs | ChEMBL. | 17998163 |
GI50 (functional) | > 100 uM | Antiproliferative activity against human M21 cells after 48 hrs | ChEMBL. | 17998163 |
GI50 (functional) | > 100 uM | Antiproliferative activity against human MCF7 cells after 48 hrs | ChEMBL. | 17998163 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.