Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Concentration (functional) | = 24 uM | NO-releasing ability under the oxidation by horseradishperoxidase (HRP) in the presence of H2O2 for 20min, expressed as nitrite concentration | ChEMBL. | 12031330 |
k cat (functional) | = 145 min-1 | Kinetic constant for NO formation during transformation of oxyhemoglobin to methemoglobin using NADPH and molecular Oxygen in the presence of (NOS II) | ChEMBL. | 11831907 |
Km (functional) | = 2600 uM | Kinetic constant for NO formation during oxidation by NADPH and molecular Oxygen with NOS II | ChEMBL. | 11831907 |
NOHA (functional) | < 0.2 % | Nitric oxide (NO) formation during oxidation of NADPH and O2, catalyzed by NOS III was detected spectrophotometrically using hemoglobin assay | ChEMBL. | 11831907 |
NOHA (functional) | = 3.5 % | Nitric oxide (NO) formation during oxidation of NADPH and O2, catalyzed by NOS I was detected spectrophotometrically using hemoglobin assay | ChEMBL. | 11831907 |
NOHA (functional) | = 8 % | Nitric oxide (NO) formation during oxidation of NADPH and O2, catalyzed by NOS II detected spectrophotometrically using hemoglobin assay. | ChEMBL. | 11831907 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.