Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | macrophage migration inhibitory factor 2 | 0.1592 | 0.4094 | 0.4094 |
Brugia malayi | Trypsin family protein | 0.0321 | 0.0586 | 0.0586 |
Plasmodium vivax | macrophage migration inhibitory factor, putative | 0.3731 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) | 0.0108 | 0 | 0.5 |
Onchocerca volvulus | 0.0964 | 0.2362 | 1 | |
Echinococcus granulosus | 6 phosphofructokinase | 0.0108 | 0 | 0.5 |
Leishmania major | macrophage migration inhibitory factor-like protein | 0.3731 | 1 | 1 |
Entamoeba histolytica | macrophage migration inhibitory factor-like protein | 0.3731 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0317 | 0.0575 | 0.0575 |
Toxoplasma gondii | macrophage migration inhibitory factor, putative | 0.3731 | 1 | 0.5 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0427 | 0.0878 | 0.0878 |
Loa Loa (eye worm) | hypothetical protein | 0.0218 | 0.0302 | 0.0302 |
Trichomonas vaginalis | conserved hypothetical protein | 0.3731 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0427 | 0.0878 | 0.0878 |
Giardia lamblia | Macrophage migration inhibitory factor | 0.3731 | 1 | 0.5 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0427 | 0.0878 | 0.0878 |
Plasmodium falciparum | macrophage migration inhibitory factor | 0.3731 | 1 | 0.5 |
Mycobacterium ulcerans | 6-phosphofructokinase | 0.0108 | 0 | 0.5 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0427 | 0.0878 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0321 | 0.0586 | 0.0586 |
Loa Loa (eye worm) | macrophage migration inhibitory factor | 0.3731 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0121 | 0.0036 | 0.0036 |
Loa Loa (eye worm) | macrophage migration inhibitory factor 2 | 0.1592 | 0.4094 | 0.4094 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0321 | 0.0586 | 1 |
Leishmania major | macrophage migration inhibitory factor-like protein | 0.3731 | 1 | 1 |
Mycobacterium leprae | PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) | 0.0108 | 0 | 0.5 |
Echinococcus multilocularis | 6 phosphofructokinase | 0.0108 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0321 | 0.0586 | 0.0586 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0427 | 0.0878 | 1 |
Trichomonas vaginalis | macrophage migration inhibitory factor, mif, putative | 0.3731 | 1 | 1 |
Treponema pallidum | diphosphate--fructose-6-phosphate 1-phosphotransferase | 0.0108 | 0 | 0.5 |
Onchocerca volvulus | 0.0321 | 0.0586 | 0.0725 | |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0321 | 0.0586 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 58 % | Inhibition of RNA copy numbers in HCV 1b-N replicon cells with NS5B M414T mutant at EC50 after 4 days | ChEMBL. | 17371824 |
Activity (functional) | = 93 % | Inhibition of RNA copy numbers in HCV 1b-N replicon cells with NS5B M414T mutant at 10 times EC50 after 4 days | ChEMBL. | 17371824 |
Activity (functional) | = 99 % | Inhibition of RNA copy numbers in HCV 1b-N replicon cells with NS5B M414T mutant at 100 times EC50 after 4 days | ChEMBL. | 17371824 |
EC50 (functional) | = 4 nM | Antiviral activity against HCV 1b-N | ChEMBL. | 17371824 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.