Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | coagulation factor X | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Glycosyl transferase family 35 | 0.0561 | 1 | 0.5 |
Schistosoma mansoni | glycogen phosphorylase | 0.0561 | 1 | 1 |
Chlamydia trachomatis | glycogen phosphorylase | 0.0561 | 1 | 0.5 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0561 | 1 | 0.5 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.0561 | 1 | 0.5 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0561 | 1 | 1 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0561 | 1 | 0.5 |
Giardia lamblia | Glycogen phosphorylase | 0.0561 | 1 | 0.5 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.0561 | 1 | 0.5 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.0561 | 1 | 0.5 |
Echinococcus granulosus | glycogen phosphorylase | 0.0561 | 1 | 0.5 |
Schistosoma mansoni | glycogen phosphorylase | 0.0561 | 1 | 1 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0561 | 1 | 0.5 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0561 | 1 | 0.5 |
Echinococcus granulosus | glycogen phosphorylase | 0.0561 | 1 | 0.5 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0561 | 1 | 1 |
Mycobacterium ulcerans | glycogen phosphorylase GlgP | 0.0243 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable glycogen phosphorylase GlgP | 0.0243 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 0.79 uM | Anticoagulant activity in human plasma assessed as concentration required to double prothrombin time | ChEMBL. | 18039572 |
IC50 (binding) | = 8.4 nM | Inhibition of human factor 10a | ChEMBL. | 18039572 |
IC50 (binding) | = 8.4 nM | Inhibition of human factor 10a | ChEMBL. | 18039572 |
IC50 (binding) | = 8.4 nM | Inhibition of factor 10a | ChEMBL. | 20503967 |
Inhibition (functional) | = 68.1 % | Ex vivo inhibition of factor 10a in Wistar rat plasma at 10 mg/kg, po after 4 hrs | ChEMBL. | 18039572 |
Inhibition (functional) | = 73.7 % | Ex vivo inhibition of factor 10a in Wistar rat plasma at 10 mg/kg, po after 2 hrs | ChEMBL. | 18039572 |
Inhibition (functional) | = 78.6 % | Ex vivo inhibition of factor 10a in Wistar rat plasma at 10 mg/kg, po after 1 hr | ChEMBL. | 18039572 |
Inhibition (functional) | = 80.2 % | Ex vivo inhibition of factor 10a in Wistar rat plasma at 10 mg/kg, po after 0.5 hrs | ChEMBL. | 18039572 |
Solubility | = 56 ug ml-1 | Solubility in japanese pharmacopoeia second fluid at pH 6.8 | ChEMBL. | 18039572 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.