Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | P2X purinoceptor 7 | Starlite/ChEMBL | References |
Homo sapiens | purinergic receptor P2X, ligand-gated ion channel, 7 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | phenylalanyl-tRNA synthetase alpha chain, putative | 0.0152 | 0.1477 | 0.5 |
Schistosoma mansoni | P2X receptor subunit | 0.0164 | 0.1653 | 1 |
Treponema pallidum | phenylalanyl-tRNA synthetase subunit alpha | 0.0152 | 0.1477 | 0.5 |
Schistosoma mansoni | phenylalanyl-tRNA synthetase subunit alpha | 0.0152 | 0.1477 | 0.8937 |
Mycobacterium tuberculosis | Probable phenylalanyl-tRNA synthetase, alpha chain PheS | 0.0725 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | phenylalanyl-tRNA synthetase subunit alpha | 0.0725 | 1 | 0.5 |
Brugia malayi | phenylalanyl (f) trna synthetase protein 1 | 0.0152 | 0.1477 | 1 |
Giardia lamblia | Phenylalanyl-tRNA synthetase alpha chain | 0.0152 | 0.1477 | 0.5 |
Echinococcus multilocularis | phenylalanyl tRNA synthetase alpha chain B | 0.0152 | 0.1477 | 0.8937 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.0164 | 0.1653 | 1 |
Plasmodium falciparum | phenylalanine--tRNA ligase alpha subunit | 0.0152 | 0.1477 | 0.5 |
Mycobacterium leprae | Probable phenylalanyl-tRNA synthetase, alpha chain PheS | 0.0108 | 0.0822 | 0.5 |
Schistosoma mansoni | P2X receptor subunit | 0.0164 | 0.1653 | 1 |
Echinococcus granulosus | phenylalanyl tRNA synthetase alpha chain B | 0.0152 | 0.1477 | 0.8937 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0164 | 0.1653 | 1 |
Entamoeba histolytica | phenylalanyl-tRNA synthetase alpha subunit, putative | 0.0152 | 0.1477 | 0.5 |
Schistosoma mansoni | P2X receptor subunit | 0.0164 | 0.1653 | 1 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0164 | 0.1653 | 1 |
Schistosoma mansoni | P2X receptor subunit | 0.0164 | 0.1653 | 1 |
Leishmania major | phenylalanyl-tRNA synthetase alpha chain, putative | 0.0152 | 0.1477 | 0.5 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.0164 | 0.1653 | 1 |
Trypanosoma brucei | phenylalanyl-tRNA synthetase alpha chain, putative | 0.0152 | 0.1477 | 0.5 |
Mycobacterium ulcerans | phenylalanyl-tRNA synthetase subunit alpha | 0.0725 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.1477 | 1 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.0164 | 0.1653 | 1 |
Trichomonas vaginalis | phenylalanyl-tRNA synthetase alpha chain, putative | 0.0152 | 0.1477 | 0.5 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0164 | 0.1653 | 1 |
Toxoplasma gondii | phenylalanyl-tRNA synthetase alpha chain A, putative | 0.0152 | 0.1477 | 0.5 |
Plasmodium vivax | phenylalanine--tRNA ligase alpha subunit, putative | 0.0152 | 0.1477 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.22 uM | Antagonist activity at human recombinant P2X7 receptor assessed as inhibition of calcium flux by FLIPR assay | ChEMBL. | 18272365 |
IC50 (functional) | = 0.22 uM | Antagonist activity at human recombinant P2X7 receptor assessed as inhibition of calcium flux by FLIPR assay | ChEMBL. | 18272365 |
IC50 (functional) | = 0.25 uM | Antagonist activity at rat recombinant P2X7 receptor assessed as inhibition of calcium flux by FLIPR assay | ChEMBL. | 18272365 |
IC50 (functional) | = 0.25 uM | Antagonist activity at rat recombinant P2X7 receptor assessed as inhibition of calcium flux by FLIPR assay | ChEMBL. | 18272365 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.