Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) | Starlite/ChEMBL | References |
Homo sapiens | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0071 | 0.2186 | 0.568 | |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.01 | 0.4345 | 0.4345 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0051 | 0.0689 | 0.5 |
Loa Loa (eye worm) | CAMK/PKD protein kinase | 0.007 | 0.2082 | 0.2082 |
Onchocerca volvulus | 0.0069 | 0.2031 | 0.5275 | |
Schistosoma mansoni | hypothetical protein | 0.006 | 0.1321 | 0.1321 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.2031 | 0.2031 |
Loa Loa (eye worm) | camk/mapkapk/mapkapk protein kinase | 0.0175 | 1 | 1 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0093 | 0.3849 | 1 |
Brugia malayi | Matrixin family protein | 0.0102 | 0.4481 | 0.4481 |
Schistosoma mansoni | protein kinase C mu | 0.007 | 0.2082 | 0.2082 |
Loa Loa (eye worm) | matrixin family protein | 0.0102 | 0.4481 | 0.4481 |
Brugia malayi | Hemopexin family protein | 0.006 | 0.1321 | 0.1321 |
Onchocerca volvulus | 0.006 | 0.1321 | 0.3431 | |
Loa Loa (eye worm) | CAMK/PKD protein kinase | 0.0062 | 0.1509 | 0.1509 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.1457 | 0.1457 |
Brugia malayi | C1-like domain containing protein | 0.007 | 0.2082 | 0.2082 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0175 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.2186 | 0.2186 |
Echinococcus granulosus | MAP kinase activated protein kinase 2 | 0.0175 | 1 | 1 |
Onchocerca volvulus | 0.0062 | 0.1457 | 0.3786 | |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0689 | 0.0689 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0051 | 0.0689 | 0.5 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0051 | 0.0689 | 0.0689 |
Onchocerca volvulus | Matrilysin homolog | 0.0093 | 0.3849 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.1457 | 0.1457 |
Echinococcus multilocularis | MAP kinase activated protein kinase 2 | 0.0175 | 1 | 1 |
Mycobacterium ulcerans | hydrolase | 0.0051 | 0.0689 | 0.5 |
Brugia malayi | Phorbol esters/diacylglycerol binding domain | 0.007 | 0.2082 | 0.2082 |
Loa Loa (eye worm) | matrixin family protein | 0.0093 | 0.3849 | 0.3849 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 4.9 nM | Inhibition of MMP9 (unknown origin) | ChEMBL. | 17981034 |
IC50 (binding) | = 4.9 nM | Inhibition of MMP9 (unknown origin) | ChEMBL. | 17981034 |
IC50 (binding) | = 6.1 nM | Inhibition of MMP2 (unknown origin) | ChEMBL. | 17981034 |
IC50 (binding) | = 6.1 nM | Inhibition of MMP2 (unknown origin) | ChEMBL. | 17981034 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.