Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | erb-b2 receptor tyrosine kinase 2 | Starlite/ChEMBL | References |
Homo sapiens | epidermal growth factor receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tyrosine kinase | 0.036 | 1 | 1 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.036 | 1 | 1 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.033 | 0.8784 | 0.5 |
Brugia malayi | carbohydrate phosphorylase | 0.033 | 0.8784 | 0.8766 |
Schistosoma mansoni | tyrosine kinase | 0.0194 | 0.3299 | 0.32 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.033 | 0.8784 | 0.8784 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.033 | 0.8784 | 0.5 |
Chlamydia trachomatis | glycogen phosphorylase | 0.033 | 0.8784 | 0.5 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.033 | 0.8784 | 1 |
Schistosoma mansoni | glycogen phosphorylase | 0.0143 | 0.1253 | 0.1125 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0194 | 0.3299 | 0.3299 |
Echinococcus multilocularis | insulin receptor | 0.0115 | 0.0145 | 0.0145 |
Schistosoma mansoni | tyrosine kinase | 0.0191 | 0.3217 | 0.3117 |
Mycobacterium ulcerans | glycogen phosphorylase GlgP | 0.0143 | 0.1253 | 0.5 |
Echinococcus multilocularis | glycogen phosphorylase | 0.033 | 0.8784 | 0.8784 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.036 | 1 | 1 |
Giardia lamblia | Glycogen phosphorylase | 0.033 | 0.8784 | 0.5 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0194 | 0.3299 | 0.32 |
Echinococcus granulosus | glycogen phosphorylase | 0.033 | 0.8784 | 0.8766 |
Echinococcus granulosus | epidermal growth factor receptor | 0.036 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0191 | 0.3217 | 0.3117 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0115 | 0.0145 | 0.0145 |
Echinococcus multilocularis | glycogen phosphorylase | 0.033 | 0.8784 | 0.8784 |
Mycobacterium tuberculosis | Probable glycogen phosphorylase GlgP | 0.0143 | 0.1253 | 0.5 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.033 | 0.8784 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0191 | 0.3217 | 0.3117 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.033 | 0.8784 | 1 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.033 | 0.8784 | 0.8766 |
Schistosoma mansoni | tyrosine kinase | 0.0194 | 0.3299 | 0.32 |
Echinococcus granulosus | glycogen phosphorylase | 0.033 | 0.8784 | 0.8766 |
Schistosoma mansoni | glycogen phosphorylase | 0.033 | 0.8784 | 0.8766 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0194 | 0.3299 | 0.32 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.033 | 0.8784 | 0.8766 |
Schistosoma mansoni | glycogen phosphorylase | 0.033 | 0.8784 | 0.8766 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.011 uM | Inhibition of erbB2 (unknown origin) | ChEMBL. | 18182285 |
IC50 (binding) | = 0.011 uM | Inhibition of erbB2 (unknown origin) | ChEMBL. | 18182285 |
IC50 (binding) | = 0.216 uM | Inhibition of EGFR (unknown origin) | ChEMBL. | 18182285 |
IC50 (binding) | = 0.216 uM | Inhibition of EGFR (unknown origin) | ChEMBL. | 18182285 |
IC50 (binding) | = 0.415 uM | Inhibition of erB2 (unknown origin) autophosphorylation in clone 24 cells | ChEMBL. | 18182285 |
IC50 (binding) | = 0.415 uM | Inhibition of erB2 (unknown origin) autophosphorylation in clone 24 cells | ChEMBL. | 18182285 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.