Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | membrane associated proteins in eicosanoid and glutathione metabolism family member | 0.0519 | 1 | 1 |
Onchocerca volvulus | 0.034 | 0.2994 | 1 | |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.034 | 0.2994 | 0.2594 |
Schistosoma mansoni | microsomal glutathione s-transferase | 0.0519 | 1 | 1 |
Onchocerca volvulus | Arrow homolog | 0.0277 | 0.054 | 0.1803 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.034 | 0.2994 | 0.2594 |
Loa Loa (eye worm) | hypothetical protein | 0.034 | 0.2994 | 1 |
Toxoplasma gondii | MAPEG family protein | 0.0519 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.034 | 0.2994 | 1 |
Echinococcus multilocularis | microsomal glutathione S transferase 3 | 0.0519 | 1 | 1 |
Brugia malayi | Trypsin family protein | 0.034 | 0.2994 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 1.5 % | Induction of differentiation in human HL60 cells at 200 nM after 72 hrs by NBT assay | ChEMBL. | 18024133 |
Activity (functional) | = 1.5 % | Induction of differentiation in human HL60 cells at 200 nM after 72 hrs by NBT assay | ChEMBL. | 18024133 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.