Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | v-rel avian reticuloendotheliosis viral oncogene homolog A | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | glycogen phosphorylase | 0.0215 | 1 | 1 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0215 | 1 | 1 |
Mycobacterium ulcerans | glycogen phosphorylase GlgP | 0.0093 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable glycogen phosphorylase GlgP | 0.0093 | 0 | 0.5 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.0215 | 1 | 0.5 |
Schistosoma mansoni | glycogen phosphorylase | 0.0215 | 1 | 1 |
Echinococcus granulosus | glycogen phosphorylase | 0.0215 | 1 | 1 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0215 | 1 | 0.5 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0215 | 1 | 1 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0215 | 1 | 1 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.0215 | 1 | 1 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0215 | 1 | 0.5 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0215 | 1 | 1 |
Giardia lamblia | Glycogen phosphorylase | 0.0215 | 1 | 0.5 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.0215 | 1 | 0.5 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.0215 | 1 | 1 |
Chlamydia trachomatis | glycogen phosphorylase | 0.0215 | 1 | 0.5 |
Schistosoma mansoni | glycogen phosphorylase | 0.0215 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | Induction of human IkappaBalpha stabilization in OCI-Ly3 cells by green light emiting IkappaBalpha-fused luciferase reporter gene assay | ChEMBL. | 18024113 | |
EC50 (binding) | Induction of human IkappaBalpha stabilization in OCI-Ly3 cells assessed as ratio of green light emiting IkappaBalpha-fused luciferase expression to red light emiting native luciferase expression | ChEMBL. | 18024113 | |
EC50 (binding) | 0 | Induction of human IkappaBalpha stabilization in OCI-Ly3 cells by green light emiting IkappaBalpha-fused luciferase reporter gene assay | ChEMBL. | 18024113 |
EC50 (binding) | 0 | Induction of human IkappaBalpha stabilization in OCI-Ly3 cells assessed as ratio of green light emiting IkappaBalpha-fused luciferase expression to red light emiting native luciferase expression | ChEMBL. | 18024113 |
Efficacy (binding) | > 90 % | Inhibition of TNFalpha-stimulated human NFkappaB p65 RelA subunit nuclear translocation in HUVEC relative to control | ChEMBL. | 18024113 |
Efficacy (binding) | > 90 % | Inhibition of TNFalpha-stimulated human NFkappaB p65 RelA subunit nuclear translocation in HUVEC relative to control | ChEMBL. | 18024113 |
IC50 (binding) | 0 | Inhibition of TNFalpha stimulated human NFkappaB-mediated beta lactamase gene expression in HUVEC | ChEMBL. | 18024113 |
IC50 (functional) | 0 | Cytotoxicity against NFkappaB overexpressing human OCI-Ly3 cells after 4 hrs | ChEMBL. | 18024113 |
IC50 (binding) | = 2.5 uM | Inhibition of TNFalpha-stimulated human NFkappaB p65 RelA subunit nuclear translocation in HUVEC | ChEMBL. | 18024113 |
IC50 (binding) | = 2.5 uM | Inhibition of TNFalpha-stimulated human NFkappaB p65 RelA subunit nuclear translocation in HUVEC | ChEMBL. | 18024113 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.