Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tyrosine kinase | 0.0141 | 0.3294 | 1 |
Echinococcus granulosus | activated cdc42 kinase 1 | 0.0363 | 1 | 1 |
Onchocerca volvulus | Dual oxidase homolog | 0.0032 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0361 | 0.9944 | 0.9944 |
Echinococcus multilocularis | transfer RNA-Thr | 0.0363 | 1 | 1 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0032 | 0 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0032 | 0 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0032 | 0 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.0141 | 0.3294 | 0.3294 |
Onchocerca volvulus | 0.0032 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0.3294 | 0.3294 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.3238 | 0.3238 |
Onchocerca volvulus | 0.0032 | 0 | 0.5 | |
Onchocerca volvulus | 0.0032 | 0 | 0.5 | |
Onchocerca volvulus | Peroxidase homolog | 0.0032 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0363 | 1 | 1 |
Echinococcus multilocularis | protein KINase family member (kin 25) | 0.0141 | 0.3294 | 0.3294 |
Echinococcus granulosus | activated cdc42 kinase 1 | 0.0363 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0032 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.3238 | 0.3238 |
Echinococcus multilocularis | activated cdc42 kinase 1 | 0.0363 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2.89751 | Inhibition of COX2 in Homo sapiens (human) whole blood | ChEMBL. | No reference |
IC50 (binding) | = 789.8 nM | Inhibition of human COX2 in human whole blood | ChEMBL. | 18158247 |
IC50 (binding) | = 789.8 nM | Inhibition of human COX2 in human whole blood | ChEMBL. | 18158247 |
IC50 (binding) | = 789.8 nM | Inhibition of COX2 in Homo sapiens (human) whole blood | ChEMBL. | No reference |
IC50 (binding) | = 7760 nM | Inhibition of human COX2 | ChEMBL. | 18158247 |
IC50 (binding) | = 7760 nM | Inhibition of human COX2 | ChEMBL. | 18158247 |
Ratio IC50 (binding) | = 0.1 | Ratio of IC50 for COX2 in human whole blood to IC50 for human purified COX2 | ChEMBL. | 18158247 |
Ratio IC50 (binding) | = 0.1 | Ratio of IC50 for COX2 in human whole blood to IC50 for human purified COX2 | ChEMBL. | 18158247 |
Ratio IC50 (binding) | > 13 | Ratio of IC50 for human COX1 to IC50 for human COX2 | ChEMBL. | 18158247 |
Ratio IC50 (binding) | > 127 | Ratio of IC50 for human COX1 to IC50 for human COX2 in human whole blood | ChEMBL. | 18158247 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.