Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | calcium:calmodulin dependent protein kinase type | 0.0047 | 0.0271 | 0.0006 |
Echinococcus multilocularis | kinesin family 1 | 0.1715 | 1 | 1 |
Toxoplasma gondii | calcium-dependent protein kinase CDPK2A | 0.0047 | 0.0271 | 0.2093 |
Toxoplasma gondii | calcium-dependent protein kinase CDPK3 | 0.0047 | 0.0271 | 0.2093 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase type | 0.0047 | 0.0271 | 0.0006 |
Plasmodium falciparum | kinesin-5 | 0.0223 | 0.1294 | 1 |
Brugia malayi | Kinesin motor domain containing protein | 0.0223 | 0.1294 | 1 |
Trypanosoma cruzi | CAMK/CAMKL family protein kinase, putative | 0.0001 | 0 | 0.5 |
Plasmodium vivax | kinesin-5 | 0.0223 | 0.1294 | 1 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase type 1 | 0.0047 | 0.0271 | 0.0006 |
Leishmania major | protein kinase, putative | 0.0047 | 0.0271 | 1 |
Trypanosoma cruzi | CAMK/CAMKL family protein kinase, putative | 0.0001 | 0 | 0.5 |
Toxoplasma gondii | calcium-dependent protein kinase CDPK2B | 0.0047 | 0.0271 | 0.2093 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0047 | 0.0271 | 0.5 |
Echinococcus multilocularis | calcium:calmodulin dependent protein kinase type | 0.0047 | 0.0271 | 0.0006 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase type | 0.0047 | 0.0271 | 0.0006 |
Entamoeba histolytica | kinesin, putative | 0.0223 | 0.1294 | 1 |
Giardia lamblia | Kinesin-5 | 0.0223 | 0.1294 | 0.5 |
Echinococcus multilocularis | calcium:calmodulin dependent protein kinase type | 0.0047 | 0.0271 | 0.0006 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase type | 0.0047 | 0.0271 | 0.0006 |
Trypanosoma brucei | calcium/calmodulin-dependent protein kinase, putative | 0.0047 | 0.0271 | 1 |
Toxoplasma gondii | kinesin motor domain-containing protein | 0.0223 | 0.1294 | 1 |
Loa Loa (eye worm) | kinesin-like protein KLP2 | 0.0223 | 0.1294 | 1 |
Echinococcus multilocularis | calcium:calmodulin dependent protein kinase type | 0.0047 | 0.0271 | 0.0006 |
Schistosoma mansoni | hypothetical protein | 0.1492 | 0.87 | 1 |
Schistosoma mansoni | kinesin eg-5 | 0.0223 | 0.1294 | 0.1214 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 5 % | Antitumor activity against mouse Ehrlich ascites carcinoma cells at 25 ug/ml relative to doxorubicin after 2 hrs | ChEMBL. | 17962022 |
Activity (functional) | = 5 % | Antitumor activity against mouse Ehrlich ascites carcinoma cells at 25 ug/ml relative to doxorubicin after 2 hrs | ChEMBL. | 17962022 |
Activity (functional) | = 20 % | Antitumor activity against mouse Ehrlich ascites carcinoma cells at 50 ug/ml relative to doxorubicin after 2 hrs | ChEMBL. | 17962022 |
Activity (functional) | = 20 % | Antitumor activity against mouse Ehrlich ascites carcinoma cells at 50 ug/ml relative to doxorubicin after 2 hrs | ChEMBL. | 17962022 |
Activity (functional) | = 35 % | Antitumor activity against mouse Ehrlich ascites carcinoma cells at 100 ug/ml relative to doxorubicin after 2 hrs | ChEMBL. | 17962022 |
Activity (functional) | = 35 % | Antitumor activity against mouse Ehrlich ascites carcinoma cells at 100 ug/ml relative to doxorubicin after 2 hrs | ChEMBL. | 17962022 |
IC50 (functional) | = 70 ug ml-1 | Antitumor activity against mouse Ehrlich ascites carcinoma cells | ChEMBL. | 17962022 |
IC50 (functional) | = 70 ug ml-1 | Antitumor activity against mouse Ehrlich ascites carcinoma cells | ChEMBL. | 17962022 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.