Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | glycogen phosphorylase | 0.0276144 | 0.5 | 0.5 |
Giardia lamblia | Glycogen phosphorylase | 0.0276144 | 0.5 | 0.5 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.0276144 | 0.5 | 0.5 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0276144 | 0.5 | 0.5 |
Echinococcus granulosus | glycogen phosphorylase | 0.0276144 | 0.5 | 0.5 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0276144 | 0.5 | 0.5 |
Chlamydia trachomatis | glycogen phosphorylase | 0.0276144 | 0.5 | 0.5 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0276144 | 0.5 | 0.5 |
Echinococcus granulosus | glycogen phosphorylase | 0.0276144 | 0.5 | 0.5 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.0276144 | 0.5 | 0.5 |
Schistosoma mansoni | glycogen phosphorylase | 0.0276144 | 0.5 | 0.5 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0276144 | 0.5 | 0.5 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0276144 | 0.5 | 0.5 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0276144 | 0.5 | 0.5 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.0276144 | 0.5 | 0.5 |
Brugia malayi | carbohydrate phosphorylase | 0.0276144 | 0.5 | 0.5 |
Schistosoma mansoni | glycogen phosphorylase | 0.0276144 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 assessed as incorporation of [3H]hypoxanthine | ChEMBL. | 18278859 | |
IC50 (functional) | 0 | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 assessed as incorporation of [3H]hypoxanthine | ChEMBL. | 18278859 |
IC50 (functional) | = 175 nM | Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D10 assessed as incorporation of [3H]hypoxanthine | ChEMBL. | 18278859 |
IC50 (functional) | = 175 nM | Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D10 assessed as incorporation of [3H]hypoxanthine | ChEMBL. | 18278859 |
IC50 (functional) | = 250 nM | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 assessed as incorporation of [3H]hypoxanthine | ChEMBL. | 18278859 |
IC50 (functional) | = 250 nM | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 assessed as incorporation of [3H]hypoxanthine | ChEMBL. | 18278859 |
IC50 (functional) | = 300 nM | Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as incorporation of [3H]hypoxanthine | ChEMBL. | 18278859 |
IC50 (functional) | = 300 nM | Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as incorporation of [3H]hypoxanthine | ChEMBL. | 18278859 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 18278859 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.