Detailed information for compound 527344
Basic information
Technical information
- TDR Targets ID: 527344
- Name: 2-Amino-4-(4-Amino-Cyclohexa-2,5-Dienyl)-Buty ric Acid
- MW: 196.246 | Formula: C10H16N2O2
-
H donors: 3
H acceptors: 2
LogP: -2.28
Rotable bonds: 4
Rule of 5 violations (Lipinski): 1 - SMILES: NC(C(=O)O)CCC1C=CC(C=C1)N
- InChi: 1S/C10H16N2O2/c11-8-4-1-7(2-5-8)3-6-9(12)10(13)14/h1-2,4-5,7-9H,3,6,11-12H2,(H,13,14)
- InChiKey: LAJWZJCOWPUSOA-UHFFFAOYSA-N
Network
Hover on a compound node to display the structore
Synonyms
- 2-amino-4-(4-aminocyclohexa-2,5-dien-1-yl)butanoic acid
- 2-amino-4-(4-amino-1-cyclohexa-2,5-dienyl)butanoic acid
- 2-azanyl-4-(4-azanylcyclohexa-2,5-dien-1-yl)butanoic acid
- 2-amino-4-(4-aminocyclohexa-2,5-dien-1-yl)butyric acid
- (2S)-2-amino-4-(4-amino-1-cyclohexa-2,5-dienyl)butanoic acid
- amiclenomycin
- 2-amino-4-(4-amino-1-cyclohexa-2,5-dienyl)butyric acid
- 53696-70-1
- 100762-88-7
- 2-Amino-4-(4-amino-2,5-cyclohexadienyl)butyric acid
- NSC246130
- Amyclenomycin
- BRN 5525177
- BUTYRIC ACID, 2-AMINO-4-(4-AMINO-2,5-CYCLOHEXADIENYL)-
Targets
Known targets for this compound
| Species | Target name | Source | Bibliographic reference |
|---|---|---|---|
| Mycobacterium leprae | PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA | Curated by TDR Targets | References |
| Mycobacterium tuberculosis | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA | Curated by TDR Targets | References |
Predicted pathogen targets for this compound
By orthology
By sequence similarity to non orthologous known druggable targets
| Species | Potential target | Known druggable target | Length | Alignment span | Identity |
|---|---|---|---|---|---|
| Mycobacterium leprae | Probable 4-aminobutyrate aminotransferase GabT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEM | PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA | 436 aa | 413 aa | 28.6 % |
| Mycobacterium leprae | Probable 4-aminobutyrate aminotransferase GabT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEM | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA | 437 aa | 397 aa | 28.5 % |
Obtained from network model
Ranking Plot
Putative Targets List
| Species | Potential target | Raw | Global | Species |
|---|
Activities
No activities found for this compound.
Phenotypes
Whole-cell/tissue/organism interactions
We have no records of whole-cell/tissue assays done with this compound
What does this mean?
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
Annotated phenotypes:
| Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Targets |
|---|---|---|---|---|---|---|
| catalytic activity (GO:0003824) | decreased (PATO:0000468) | in vitro (MI:0492) | inferred from specific protein inhibition (ECO:0000020) | Mycobacterium tuberculosis | 257127 | |
| Annotator: | crowther@u.washington.edu | Comment: | 2007-12-21 | References: | 16984394 | |
| catalytic activity (GO:0003824) | decreased (PATO:0000468) | in vitro (MI:0492) | inferred from specific protein inhibition (ECO:0000020) | Mycobacterium tuberculosis | 5713 | |
| Annotator: | crowther@u.washington.edu | Comment: | 2007-12-21 | References: | 16984394 | |
In TDR Targets, information about phenotypes that are caused by
drugs, or by genetic manipulation of cells (e.g. gene knockouts or
knockdowns) is manually curated from the literature. These
descriptions help to describe the potential of the target for drug
development. If no information is available for this gene or if the
information is incomplete, this may mean that i) the papers
containing this information either appeared after the curation
effort for this organism was carried out or they were inadvertently
missed by curators; or that ii) the curation effort for this
organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.
Bibliographic References
2 literature references were collected for this gene.
If you have references for this compound, please enter them in a user comment (below) or Contact us.