Detailed information for compound 52814

Basic information

Technical information
  • TDR Targets ID: 52814
  • Name: 5-[2-[4-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)m ethoxy]phenyl]ethyl]-1,3-thiazolidine-2,4-dio ne
  • MW: 408.47 | Formula: C22H20N2O4S
  • H donors: 1 H acceptors: 3 LogP: 4.4 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1NC(=O)C(S1)CCc1ccc(cc1)OCc1nc(oc1C)c1ccccc1
  • InChi: 1S/C22H20N2O4S/c1-14-18(23-21(28-14)16-5-3-2-4-6-16)13-27-17-10-7-15(8-11-17)9-12-19-20(25)24-22(26)29-19/h2-8,10-11,19H,9,12-13H2,1H3,(H,24,25,26)
  • InChiKey: FFVKZGIHQUNIFM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-[2-[4-[(5-methyl-2-phenyl-oxazol-4-yl)methoxy]phenyl]ethyl]thiazolidine-2,4-dione
  • 5-[2-[4-[(5-methyl-2-phenyl-4-oxazolyl)methoxy]phenyl]ethyl]thiazolidine-2,4-dione
  • 5-[2-[4-[(5-methyl-2-phenyl-oxazol-4-yl)methoxy]phenyl]ethyl]thiazolidine-2,4-quinone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0012 0 0.5
Brugia malayi putative neuropeptide receptor NPR1 0.0012 0 0.5
Treponema pallidum mcbG protein 0.008 1 0.5
Brugia malayi G-protein coupled receptor 0.0012 0 0.5
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0012 0 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0012 0 0.5
Echinococcus granulosus hypothetical protein 0.0012 0 0.5
Schistosoma mansoni hypothetical protein 0.0012 0 0.5
Echinococcus multilocularis sex peptide receptor 0.0012 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0012 0 0.5
Onchocerca volvulus 0.0012 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0012 0 0.5
Brugia malayi larval opioid receptor 0.0012 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0012 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0012 0 0.5
Onchocerca volvulus 0.0012 0 0.5
Echinococcus multilocularis G protein coupled receptor 139 0.0012 0 0.5
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0012 0 0.5
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0012 0 0.5
Brugia malayi Dopamine receptor protein 2 0.0012 0 0.5
Schistosoma mansoni hypothetical protein 0.0012 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0012 0 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0012 0 0.5
Loa Loa (eye worm) melatonin receptor type 1A 0.0012 0 0.5
Brugia malayi hypothetical protein 0.0012 0 0.5
Mycobacterium tuberculosis Conserved protein 0.008 1 0.5
Brugia malayi RE15519p 0.0012 0 0.5
Schistosoma mansoni neuropeptide receptor 0.0012 0 0.5
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0012 0 0.5
Schistosoma mansoni amine GPCR 0.0012 0 0.5
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0012 0 0.5
Echinococcus multilocularis allatostatin A receptor 0.0012 0 0.5
Schistosoma mansoni neuropeptide receptor 0.0012 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0012 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0012 0 0.5
Schistosoma mansoni hypothetical protein 0.0012 0 0.5
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0012 0 0.5
Echinococcus granulosus tm gpcr rhodopsin 0.0012 0 0.5
Echinococcus multilocularis neuropeptide receptor A26 0.0012 0 0.5
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0012 0 0.5
Brugia malayi hypothetical protein 0.0012 0 0.5
Echinococcus granulosus sex peptide receptor 0.0012 0 0.5
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0012 0 0.5
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0012 0 0.5
Brugia malayi AKH receptor 0.0012 0 0.5
Echinococcus multilocularis orexin receptor type 2 0.0012 0 0.5
Brugia malayi follicle stimulating hormone receptor 0.0012 0 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0 0.5
Schistosoma mansoni biogenic amine receptor 0.0012 0 0.5
Schistosoma mansoni adenoreceptor 0.0012 0 0.5
Echinococcus granulosus neuropeptide Y receptor 0.0012 0 0.5
Echinococcus granulosus biogenic amine 5HT receptor 0.0012 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0012 0 0.5
Echinococcus multilocularis g protein coupled receptor 0.0012 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0012 0 0.5
Echinococcus granulosus tm gpcr rhodopsin 0.0012 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0012 0 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0 0.5
Brugia malayi hypothetical protein 0.0012 0 0.5
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0012 0 0.5
Onchocerca volvulus 0.0012 0 0.5
Echinococcus multilocularis neuropeptide receptor 0.0012 0 0.5
Loa Loa (eye worm) neuropeptide F receptor 0.0012 0 0.5
Schistosoma mansoni biogenic amine (5HT) receptor 0.0012 0 0.5
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0012 0 0.5
Echinococcus multilocularis g-protein coupled receptor 0.0012 0 0.5
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0012 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0012 0 0.5
Echinococcus multilocularis neuropeptide FF receptor 2 0.0012 0 0.5
Schistosoma mansoni opsin-like receptor 0.0012 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0012 0 0.5
Schistosoma mansoni neuropeptide F-like receptor 0.0012 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0012 0 0.5
Brugia malayi sulfakinin receptor protein 0.0012 0 0.5
Brugia malayi GnHR receptor homolog 0.0012 0 0.5
Brugia malayi putative neuropeptide receptor 0.0012 0 0.5
Brugia malayi Serotonin receptor 0.0012 0 0.5
Echinococcus granulosus dro:myosuppressin receptor 0.0012 0 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.008 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0012 0 0.5
Schistosoma mansoni amine GPCR 0.0012 0 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0 0.5
Echinococcus granulosus 7tm_1 domain containing protein 0.0012 0 0.5
Schistosoma mansoni biogenic amine receptor 0.0012 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0012 0 0.5
Echinococcus granulosus tachykinin peptides receptor 99D 0.0012 0 0.5
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0012 0 0.5
Brugia malayi G-protein coupled receptor 0.0012 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0012 0 0.5
Onchocerca volvulus 0.0012 0 0.5
Echinococcus granulosus neuropeptide receptor 0.0012 0 0.5
Brugia malayi G protein-coupled receptor 0.0012 0 0.5
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0012 0 0.5
Schistosoma mansoni hypothetical protein 0.0012 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0012 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0012 0 0.5
Brugia malayi hypothetical protein 0.0012 0 0.5
Schistosoma mansoni alpha-1 adrenergic receptor 0.0012 0 0.5
Schistosoma mansoni amine GPCR 0.0012 0 0.5
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0012 0 0.5
Echinococcus granulosus neuropeptide receptor A26 0.0012 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0012 0 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0 0.5
Echinococcus multilocularis neuropeptide s receptor 0.0012 0 0.5
Echinococcus granulosus neuropeptides capa receptor 0.0012 0 0.5
Echinococcus multilocularis neuropeptide receptor 0.0012 0 0.5
Onchocerca volvulus 0.0012 0 0.5
Schistosoma mansoni neuropeptide f receptor 76f 0.0012 0 0.5
Brugia malayi hypothetical protein 0.0012 0 0.5
Schistosoma mansoni amine GPCR 0.0012 0 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0012 0 0.5
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.008 1 0.5
Schistosoma mansoni opsin-like receptor 0.0012 0 0.5
Onchocerca volvulus 0.0012 0 0.5
Schistosoma mansoni biogenic amine receptor 0.0012 0 0.5
Echinococcus multilocularis fmrfamide receptor 0.0012 0 0.5
Echinococcus granulosus g protein coupled receptor 0.0012 0 0.5
Echinococcus granulosus orexin receptor type 2 0.0012 0 0.5
Echinococcus granulosus G protein coupled receptor 139 0.0012 0 0.5
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0012 0 0.5
Mycobacterium ulcerans hypothetical protein 0.008 1 0.5
Onchocerca volvulus 0.0012 0 0.5
Brugia malayi Tachykinin-like peptides receptor 99D 0.0012 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0012 0 0.5
Schistosoma mansoni histamine h1 receptor 0.0012 0 0.5
Echinococcus granulosus neuropeptides capa receptor 0.0012 0 0.5
Echinococcus multilocularis serotonin receptor 0.0012 0 0.5
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0012 0 0.5
Echinococcus multilocularis g protein coupled receptor 0.0012 0 0.5
Schistosoma mansoni myosin xvIII 0.0012 0 0.5
Schistosoma mansoni growth hormone secretagogue receptor 0.0012 0 0.5
Schistosoma mansoni neuropeptide receptor 0.0012 0 0.5
Echinococcus granulosus neuropeptide Y receptor 0.0012 0 0.5
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0012 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0012 0 0.5
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0012 0 0.5
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0012 0 0.5
Brugia malayi hypothetical protein 0.0012 0 0.5
Echinococcus granulosus somatostatin receptor 0.0012 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0012 0 0.5
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0012 0 0.5
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0012 0 0.5
Echinococcus granulosus peptide allatostatin:somatostatin 0.0012 0 0.5
Echinococcus granulosus neuropeptide FF receptor 2 0.0012 0 0.5
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0012 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0012 0 0.5
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0012 0 0.5
Schistosoma mansoni amine GPCR 0.0012 0 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0012 0 0.5
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0012 0 0.5
Echinococcus granulosus fmrfamide receptor 0.0012 0 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0 0.5
Echinococcus granulosus 7TM GPCR rhodopsin 0.0012 0 0.5
Loa Loa (eye worm) G-protein coupled receptor 0.0012 0 0.5
Onchocerca volvulus 0.0012 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0012 0 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0 0.5
Echinococcus granulosus serotonin receptor 0.0012 0 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0 0.5
Schistosoma mansoni neuropeptide F-like receptor 0.0012 0 0.5
Onchocerca volvulus 0.0012 0 0.5
Brugia malayi G protein-coupled receptor F59B2.13 0.0012 0 0.5
Brugia malayi hypothetical protein 0.0012 0 0.5
Echinococcus granulosus tm gpcr rhodopsin 0.0012 0 0.5
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0012 0 0.5
Echinococcus granulosus g protein coupled receptor 0.0012 0 0.5
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0012 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0012 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0012 0 0.5
Brugia malayi Serotonin receptor 0.0012 0 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0 0.5
Echinococcus multilocularis dro:myosuppressin receptor 0.0012 0 0.5
Brugia malayi neuropeptide F receptor 0.0012 0 0.5
Brugia malayi hypothetical protein 0.0012 0 0.5
Leishmania major hypothetical protein, conserved 0.008 1 0.5
Brugia malayi neuropeptide F receptor 0.0012 0 0.5
Onchocerca volvulus 0.0012 0 0.5
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0012 0 0.5
Onchocerca volvulus 0.0012 0 0.5
Echinococcus granulosus biogenic amine 5HT receptor 0.0012 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0012 0 0.5
Onchocerca volvulus 0.0012 0 0.5
Brugia malayi Dopamine receptor 0.0012 0 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0 0.5
Echinococcus granulosus alpha 1A adrenergic receptor 0.0012 0 0.5
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0012 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0012 0 0.5
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0012 0 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0 0.5
Onchocerca volvulus 0.0012 0 0.5
Echinococcus multilocularis G-protein coupled receptor, putative 0.0012 0 0.5
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0012 0 0.5
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0012 0 0.5
Loa Loa (eye worm) G-protein coupled receptor 0.0012 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0012 0 0.5
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0012 0 0.5
Brugia malayi hypothetical protein 0.0012 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0012 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0012 0 0.5
Echinococcus multilocularis serotonin receptor 0.0012 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0012 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0012 0 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0 0.5
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0012 0 0.5
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0012 0 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0012 0 0.5
Echinococcus multilocularis somatostatin receptor 0.0012 0 0.5
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0012 0 0.5
Onchocerca volvulus Neuropeptide F receptor homolog 0.0012 0 0.5
Echinococcus granulosus neuropeptide receptor 0.0012 0 0.5
Loa Loa (eye worm) neuropeptide F receptor 0.0012 0 0.5
Schistosoma mansoni neuropeptide receptor 0.0012 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0012 0 0.5
Brugia malayi ORL1-like opioid receptor 0.0012 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0012 0 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0 0.5
Onchocerca volvulus 0.0012 0 0.5
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0012 0 0.5
Onchocerca volvulus 0.0012 0 0.5
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0012 0 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0 0.5
Echinococcus multilocularis neuropeptides capa receptor 0.0012 0 0.5
Schistosoma mansoni biogenic amine (5HT) receptor 0.0012 0 0.5
Brugia malayi Dopamine receptor protein 1 0.0012 0 0.5
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0012 0 0.5
Brugia malayi Melatonin receptor type 1A 0.0012 0 0.5
Echinococcus granulosus g protein coupled receptor 0.0012 0 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.008 1 0.5
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0012 0 0.5
Echinococcus granulosus g-protein coupled receptor 0.0012 0 0.5
Onchocerca volvulus 0.0012 0 0.5
Echinococcus multilocularis neuropeptides capa receptor 0.0012 0 0.5
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0012 0 0.5
Echinococcus multilocularis fmrfamide receptor 0.0012 0 0.5
Echinococcus granulosus allatostatin A receptor 0.0012 0 0.5
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0012 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0012 0 0.5
Echinococcus multilocularis g protein coupled receptor 0.0012 0 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0 0.5
Schistosoma mansoni opsin-like receptor 0.0012 0 0.5
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0012 0 0.5
Onchocerca volvulus 0.0012 0 0.5
Echinococcus granulosus neuropeptide s receptor 0.0012 0 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0 0.5
Loa Loa (eye worm) TYRA-2 protein 0.0012 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0012 0 0.5
Brugia malayi hypothetical protein 0.0012 0 0.5
Echinococcus multilocularis neuropeptide Y receptor 0.0012 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0012 0 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0012 0 0.5
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0012 0 0.5
Echinococcus multilocularis neuropeptide Y receptor 0.0012 0 0.5

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 15 Plasma lipid-lowering activity at a dosage of 0.005% in the diet in KKA(y) mice. ChEMBL. 11906293
Activity (functional) = 24 Plasma glucose-lowering activity at a dosage of 0.005% in the diet in KKA(y) mice. ChEMBL. 11906293

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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