Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.5614 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.5614 | 0.5 | 0.5 |
Loa Loa (eye worm) | NNMT/PNMT/TEMT family protein | 0.5614 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Anticonvulsant activity (functional) | Anticonvulsant activity against maximal electroshock (MES) induced seizures in mice 4 hours after ip administration of 600 mg/kg. | ChEMBL. | 3735320 | |
Anticonvulsant activity (functional) | Anticonvulsant activity against subcutaneous pentylenetetrazole induced convulsions in mice 4 hr after ip administration of 600 mg/kg. | ChEMBL. | 3735320 | |
Anticonvulsant activity (functional) | Anticonvulsant activity against maximal electroshock (MES) induced seizures in mice 30 minutes after ip administration of 600 mg/kg; A=Active | ChEMBL. | 3735320 | |
Anticonvulsant activity (functional) | Anticonvulsant activity against subcutaneous pentylenetetrazole induced convulsions in mice 30 min after ip administration of 600 mg/kg. | ChEMBL. | 3735320 | |
Anticonvulsant activity (functional) | 0 | Anticonvulsant activity against maximal electroshock (MES) induced seizures in mice 30 minutes after ip administration of 600 mg/kg; A=Active | ChEMBL. | 3735320 |
Anticonvulsant activity (functional) | NA 0 | Anticonvulsant activity against maximal electroshock (MES) induced seizures in mice 4 hours after ip administration of 600 mg/kg. | ChEMBL. | 3735320 |
Anticonvulsant activity (functional) | NA 0 | Anticonvulsant activity against subcutaneous pentylenetetrazole induced convulsions in mice 30 min after ip administration of 600 mg/kg. | ChEMBL. | 3735320 |
Anticonvulsant activity (functional) | NA 0 | Anticonvulsant activity against subcutaneous pentylenetetrazole induced convulsions in mice 4 hr after ip administration of 600 mg/kg. | ChEMBL. | 3735320 |
Toxicity (functional) | Compound was tested for toxicity by rotorod assay method in mice after intraperitoneal administration after 4 hours | ChEMBL. | 3735320 | |
Toxicity (functional) | Compound was tested for toxicity by rotorod assay method in mice after intraperitoneal administration after 30 minutes | ChEMBL. | 3735320 | |
Toxicity (functional) | NA 0 | Compound was tested for toxicity by rotorod assay method in mice after intraperitoneal administration after 30 minutes | ChEMBL. | 3735320 |
Toxicity (functional) | NA 0 | Compound was tested for toxicity by rotorod assay method in mice after intraperitoneal administration after 4 hours | ChEMBL. | 3735320 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.