Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | coagulation factor II (thrombin) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | calcium:calmodulin dependent protein kinase I | 0.0698 | 0.9996 | 0.9996 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0021 | 0 | 0.5 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0021 | 0 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0021 | 0 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0699 | 1 | 0.5 |
Toxoplasma gondii | kringle domain-containing protein | 0.0021 | 0 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0699 | 1 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase Chk2 | 0.0699 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0 | 0.5 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase I | 0.0698 | 0.9996 | 0.9996 |
Entamoeba histolytica | protein kinase, putative | 0.0699 | 1 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0021 | 0 | 0.5 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0021 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0021 | 0 | 0.5 |
Brugia malayi | Kringle domain containing protein | 0.0021 | 0 | 0.5 |
Onchocerca volvulus | 0.0021 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.