Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | NNMT/PNMT/TEMT family protein | 0.6327 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.6327 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.6327 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Binding (binding) | = 107.5 pM 30min-1 (mg of DNA)-1 | In vitro binding affinity to rat liver microsome-mediated AFB1-DNA using [3H]- AFB1 radioligand assay at concentration of 100 microM | ChEMBL. | No reference |
Binding (binding) | = 110 pM 30min-1 (mg of DNA)-1 | In vitro binding affinity to rat liver microsome-mediated AFB1-DNA using [3H]- AFB1 radioligand assay at concentration of 50 microM | ChEMBL. | No reference |
Binding (binding) | = 126.8 pM 30min-1 (mg of DNA)-1 | In vitro binding affinity to rat liver microsome-mediated AFB1-DNA using [3H]- AFB1 radioligand assay at concentration of 10 microM | ChEMBL. | No reference |
Inhibition (binding) | = 9 % | Tested in vitro for inhibition of rat liver microsome-mediated AFB1-DNA at concentration of 10 microM | ChEMBL. | No reference |
Inhibition (binding) | = 21 % | Tested in vitro for inhibition of rat liver microsome-mediated AFB1-DNA at concentration of 50 microM | ChEMBL. | No reference |
Inhibition (binding) | = 23 % | Tested in vitro for inhibition of rat liver microsome-mediated AFB1-DNA at concentration of 100 microM | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.