Detailed information for compound 532184

Basic information

Technical information
  • TDR Targets ID: 532184
  • Name: piperazine hydrochloride
  • MW: 122.597 | Formula: C4H11ClN2
  • H donors: 2 H acceptors: 0 LogP: -0.06 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: N1CCNCC1.Cl
  • InChi: 1S/C4H10N2.ClH/c1-2-6-4-3-5-1;/h5-6H,1-4H2;1H
  • InChiKey: MSQACBWWAIBWIC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • piperazin-1-ium chloride
  • piperazine
  • 7542-23-6
  • 8006-71-1
  • 6094-40-2
  • Piperazinium chloride
  • Piperazine monohydrochloride
  • EINECS 231-422-5
  • Piperazine, monohydrochloride
  • EINECS 228-042-7

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Plasmodium falciparum superoxide dismutase [Fe] Curated by TDR Targets References
Plasmodium falciparum superoxide dismutase [Fe] Curated by TDR Targets References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei iron superoxide dismutase Get druggable targets OG5_126676 All targets in OG5_126676
Plasmodium falciparum superoxide dismutase [Fe] Get druggable targets OG5_158563 All targets in OG5_158563
Mycobacterium leprae Probable superoxide dismutase SodA Get druggable targets OG5_126676 All targets in OG5_126676
Plasmodium knowlesi superoxide dismutase [Fe], putative Get druggable targets OG5_158563 All targets in OG5_158563
Cryptosporidium parvum superoxide dismutase Get druggable targets OG5_126676 All targets in OG5_126676
Leishmania donovani iron superoxide dismutase, putative Get druggable targets OG5_126676 All targets in OG5_126676
Leishmania mexicana iron superoxide dismutase, putative Get druggable targets OG5_126676 All targets in OG5_126676
Trypanosoma congolense iron superoxide dismutase A, mitochondrial Get druggable targets OG5_126676 All targets in OG5_126676
Plasmodium yoelii superoxide dismutase, C-terminal domain, putative Get druggable targets OG5_158563 All targets in OG5_158563
Leishmania major iron superoxide dismutase Get druggable targets OG5_126676 All targets in OG5_126676
Leishmania infantum iron superoxide dismutase, putative Get druggable targets OG5_126676 All targets in OG5_126676
Leishmania infantum iron superoxide dismutase Get druggable targets OG5_126676 All targets in OG5_126676
Trichomonas vaginalis iron superoxide dismutase A, putative Get druggable targets OG5_126676 All targets in OG5_126676
Trichomonas vaginalis superoxide dismutase, putative Get druggable targets OG5_126676 All targets in OG5_126676
Trichomonas vaginalis superoxide dismutase [fe], putative Get druggable targets OG5_126676 All targets in OG5_126676
Toxoplasma gondii superoxide dismutase SOD3 Get druggable targets OG5_126676 All targets in OG5_126676
Trichomonas vaginalis superoxide dismutase [mn], putative Get druggable targets OG5_126676 All targets in OG5_126676
Leishmania braziliensis iron superoxide dismutase, putative Get druggable targets OG5_126676 All targets in OG5_126676
Plasmodium vivax superoxide dismutase [Fe], putative Get druggable targets OG5_158563 All targets in OG5_158563
Cryptosporidium hominis superoxide dismutase Get druggable targets OG5_126676 All targets in OG5_126676
Leishmania mexicana iron superoxide dismutase, putative Get druggable targets OG5_126676 All targets in OG5_126676
Onchocerca volvulus Superoxide dismutase [Mn], mitochondrial homolog Get druggable targets OG5_126676 All targets in OG5_126676
Trypanosoma cruzi iron superoxide dismutase A, mitochondrial Get druggable targets OG5_126676 All targets in OG5_126676
Trypanosoma cruzi iron superoxide dismutase, putative Get druggable targets OG5_126676 All targets in OG5_126676
Candida albicans likely mitochondrial manganese-containing superoxide dismutase similar to S. cerevisiae SOD2 (YHR008C) Get druggable targets OG5_126676 All targets in OG5_126676
Plasmodium berghei superoxide dismutase [Fe], putative Get druggable targets OG5_126676 All targets in OG5_126676
Theileria parva Fe-superoxide dismutase, putative Get druggable targets OG5_158563 All targets in OG5_158563
Schistosoma japonicum ko:K04564 superoxide dismutase, Fe-Mn family [EC1.15.1.1A], putative Get druggable targets OG5_126676 All targets in OG5_126676
Leishmania major iron superoxide dismutase, putative Get druggable targets OG5_126676 All targets in OG5_126676
Brugia malayi Superoxide dismutase, mitochondrial precursor, putative Get druggable targets OG5_126676 All targets in OG5_126676
Chlamydia trachomatis superoxide dismutase Get druggable targets OG5_126676 All targets in OG5_126676
Wolbachia endosymbiont of Brugia malayi superoxide dismutase, SodA Get druggable targets OG5_126676 All targets in OG5_126676
Toxoplasma gondii superoxide dismutase Get druggable targets OG5_126676 All targets in OG5_126676
Leishmania braziliensis iron superoxide dismutase Get druggable targets OG5_126676 All targets in OG5_126676
Onchocerca volvulus Superoxide dismutase [Mn], mitochondrial homolog Get druggable targets OG5_126676 All targets in OG5_126676
Echinococcus multilocularis manganese superoxide dismutase Get druggable targets OG5_126676 All targets in OG5_126676
Schistosoma mansoni superoxide dismutase [mn] Get druggable targets OG5_126676 All targets in OG5_126676
Trypanosoma cruzi iron superoxide dismutase, putative Get druggable targets OG5_126676 All targets in OG5_126676
Babesia bovis superoxide dismutase, putative Get druggable targets OG5_126676 All targets in OG5_126676
Trypanosoma cruzi iron superoxide dismutase A, mitochondrial Get druggable targets OG5_126676 All targets in OG5_126676
Mycobacterium tuberculosis Superoxide dismutase [FE] SodA Get druggable targets OG5_126676 All targets in OG5_126676
Plasmodium berghei superoxide dismutase [Fe], putative Get druggable targets OG5_158563 All targets in OG5_158563
Trypanosoma brucei gambiense iron superoxide dismutase, putative Get druggable targets OG5_126676 All targets in OG5_126676
Leishmania infantum iron superoxide dismutase, putative Get druggable targets OG5_126676 All targets in OG5_126676
Plasmodium falciparum superoxide dismutase [Fe] Get druggable targets OG5_126676 All targets in OG5_126676
Trypanosoma congolense iron superoxide dismutase Get druggable targets OG5_126676 All targets in OG5_126676
Trypanosoma brucei gambiense iron superoxide dismutase, putative Get druggable targets OG5_126676 All targets in OG5_126676
Trypanosoma brucei iron superoxide dismutase Get druggable targets OG5_126676 All targets in OG5_126676
Entamoeba histolytica iron-containing superoxide dismutase Get druggable targets OG5_126676 All targets in OG5_126676
Neospora caninum superoxide dismutase Get druggable targets OG5_126676 All targets in OG5_126676
Plasmodium vivax superoxide dismutase [Fe], putative Get druggable targets OG5_126676 All targets in OG5_126676
Trichomonas vaginalis superoxide dismutase, putative Get druggable targets OG5_126676 All targets in OG5_126676
Toxoplasma gondii superoxide dismutase SOD2 Get druggable targets OG5_126676 All targets in OG5_126676
Trichomonas vaginalis superoxide dismutase [fe], putative Get druggable targets OG5_126676 All targets in OG5_126676
Echinococcus granulosus manganese superoxide dismutase Get druggable targets OG5_126676 All targets in OG5_126676
Leishmania donovani iron superoxide dismutase, putative Get druggable targets OG5_126676 All targets in OG5_126676
Plasmodium yoelii Iron/manganese superoxide dismutases, putative Get druggable targets OG5_126676 All targets in OG5_126676
Mycobacterium ulcerans superoxide dismutase [Fe] SodA Get druggable targets OG5_126676 All targets in OG5_126676
Trypanosoma brucei iron superoxide dismutase A, mitochondrial Get druggable targets OG5_126676 All targets in OG5_126676
Leishmania major iron superoxide dismutase, putative Get druggable targets OG5_126676 All targets in OG5_126676
Candida albicans likely mitochondrial manganese-containing superoxide dismutase similar to S. cerevisiae SOD2 (YHR008C) Get druggable targets OG5_126676 All targets in OG5_126676
Neospora caninum Superoxide dismutase (EC 1.15.1.1), related Get druggable targets OG5_126676 All targets in OG5_126676
Trichomonas vaginalis superoxide dismutase [fe], putative Get druggable targets OG5_126676 All targets in OG5_126676
Trypanosoma brucei gambiense iron superoxide dismutase, putative Get druggable targets OG5_126676 All targets in OG5_126676
Leishmania braziliensis iron superoxide dismutase, putative Get druggable targets OG5_126676 All targets in OG5_126676
Leishmania mexicana iron superoxide dismutase Get druggable targets OG5_126676 All targets in OG5_126676
Onchocerca volvulus Superoxide dismutase [Mn], mitochondrial homolog Get druggable targets OG5_126676 All targets in OG5_126676
Trypanosoma cruzi iron superoxide dismutase, putative Get druggable targets OG5_126676 All targets in OG5_126676
Theileria parva iron-dependent superoxide dismutase, putative Get druggable targets OG5_126676 All targets in OG5_126676
Trypanosoma cruzi iron superoxide dismutase, putative Get druggable targets OG5_126676 All targets in OG5_126676
Plasmodium knowlesi superoxide dismutase [Fe], putative Get druggable targets OG5_126676 All targets in OG5_126676
Trypanosoma congolense iron superoxide dismutase Get druggable targets OG5_126676 All targets in OG5_126676
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126676 All targets in OG5_126676
Candida albicans hypothetical protein Get druggable targets OG5_126676 All targets in OG5_126676
Leishmania donovani iron superoxide dismutase A, mitochondrial Get druggable targets OG5_126676 All targets in OG5_126676
Neospora caninum Superoxide dismutase (EC 1.15.1.1), related Get druggable targets OG5_126676 All targets in OG5_126676
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum superoxide dismutase [Fe] superoxide dismutase [Fe] 198 aa 191 aa 52.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Targets
growth (GO:0040007) lethal (sensu genetics) (PATO:0000718) multi-cellular organism (CARO:0000012) bloodstream stage (PLO:0040) in vivo inhibition (TDR:00016) Plasmodium falciparum 1004  
Annotator: saralph@unimelb.edu.au Comment: 012/Mar/09 References: 14604655 14962361 2666151
growth (GO:0040007) lethal (sensu genetics) (PATO:0000718) multi-cellular organism (CARO:0000012) bloodstream stage (PLO:0040) in vivo inhibition (TDR:00016) Plasmodium falciparum 4583  
Annotator: saralph@unimelb.edu.au Comment: 012/Mar/09 References: 14604655 14962361 2666151

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

7 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.