Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | galactoside-binding lectin family protein | 0.0441 | 0.5 | 0.5 |
Schistosoma mansoni | galectin | 0.0441 | 0.5 | 0.5 |
Loa Loa (eye worm) | galactoside-binding lectin family protein | 0.0441 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0441 | 0.5 | 0.5 |
Loa Loa (eye worm) | galectin | 0.0441 | 0.5 | 0.5 |
Loa Loa (eye worm) | galactoside-binding lectin family protein | 0.0441 | 0.5 | 0.5 |
Echinococcus granulosus | Galectin carbohydrate recognition domain | 0.0441 | 0.5 | 0.5 |
Brugia malayi | Galactoside-binding lectin family protein | 0.0441 | 0.5 | 0.5 |
Brugia malayi | Galactoside-binding lectin family protein | 0.0441 | 0.5 | 0.5 |
Brugia malayi | galectin | 0.0441 | 0.5 | 0.5 |
Echinococcus multilocularis | Galectin, carbohydrate recognition domain | 0.0441 | 0.5 | 0.5 |
Onchocerca volvulus | Galectin homolog | 0.0441 | 0.5 | 0.5 |
Brugia malayi | Galactoside-binding lectin family protein | 0.0441 | 0.5 | 0.5 |
Loa Loa (eye worm) | galectin | 0.0441 | 0.5 | 0.5 |
Brugia malayi | galectin | 0.0441 | 0.5 | 0.5 |
Onchocerca volvulus | Galectin homolog | 0.0441 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0441 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0441 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 40 % | Effect on diacylglycerol induced (DAG) PKC activation at 1-10 microM | ChEMBL. | 12699748 |
Activity (functional) | = 40 % | Effect on diacylglycerol induced (DAG) PKC activation at 1-10 microM | ChEMBL. | 12699748 |
Km (binding) | = 140 uM | Activation of purified human recombinant Protein Kinase C alpha | ChEMBL. | 12699748 |
Km (binding) | = 140 uM | Activation of purified human recombinant Protein Kinase C alpha | ChEMBL. | 12699748 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.