Detailed information for compound 53560

Basic information

Technical information
  • TDR Targets ID: 53560
  • Name: 1-phenyl-3-(2-sulfanylidene-3H-1,3,4-thiadiaz ol-5-yl)urea
  • MW: 252.316 | Formula: C9H8N4OS2
  • H donors: 2 H acceptors: 3 LogP: 1.75 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1nnc(s1)S)Nc1ccccc1
  • InChi: 1S/C9H8N4OS2/c14-7(10-6-4-2-1-3-5-6)11-8-12-13-9(15)16-8/h1-5H,(H,13,15)(H2,10,11,12,14)
  • InChiKey: FZQDTUCHCVJYHU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-phenyl-3-(2-thioxo-3H-1,3,4-thiadiazol-5-yl)urea
  • 1-phenyl-3-(5-sulfanylidene-4H-1,3,4-thiadiazol-2-yl)urea
  • 1-phenyl-3-(5-thioxo-4H-1,3,4-thiadiazol-2-yl)urea

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum cysteine repeat modular protein 1 0.0315 0.0496 0.5
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0315 0.0496 0.5
Schistosoma mansoni hypothetical protein 0.0315 0.0496 0.0496
Echinococcus granulosus tissue type plasminogen activator 0.0315 0.0496 1
Onchocerca volvulus 0.075 1 1
Echinococcus multilocularis tissue type plasminogen activator 0.0315 0.0496 1
Loa Loa (eye worm) hypothetical protein 0.0306 0.0289 0.0289
Loa Loa (eye worm) hypothetical protein 0.075 1 1
Toxoplasma gondii kringle domain-containing protein 0.0315 0.0496 0.0523
Toxoplasma gondii PAN domain-containing protein 0.0726 0.9489 1
Loa Loa (eye worm) TK/ROR protein kinase 0.0315 0.0496 0.0496
Leishmania major hypothetical protein, conserved 0.0315 0.0496 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0315 0.0496 0.5
Onchocerca volvulus 0.0315 0.0496 0.0496
Brugia malayi Protein kinase domain containing protein 0.0315 0.0496 0.0496
Loa Loa (eye worm) hypothetical protein 0.075 1 1
Onchocerca volvulus 0.0583 0.635 0.635
Brugia malayi Kringle domain containing protein 0.0315 0.0496 0.0496
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.075 1 1
Toxoplasma gondii PAN domain-containing protein 0.0726 0.9489 1
Loa Loa (eye worm) hypothetical protein 0.0315 0.0496 0.0496
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.075 1 1

Activities

Activity type Activity value Assay description Source Reference
GI (functional) Antifungal activity against Candida albicans assessed as growth inhibition measured after 24 to 48 hrs by agar disk diffusion method ChEMBL. No reference
IC50 (binding) = 99 uM Inhibitory concentration against Matrix metalloproteinase-3 ChEMBL. 10229623
IC50 (binding) = 99 uM Inhibitory concentration against Matrix metalloproteinase-3 ChEMBL. 10229623

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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