Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) | Starlite/ChEMBL | References |
Homo sapiens | matrix metallopeptidase 3 (stromelysin 1, progelatinase) | Starlite/ChEMBL | References |
Homo sapiens | matrix metallopeptidase 1 (interstitial collagenase) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | matrix metallopeptidase 3 (stromelysin 1, progelatinase) | 477 aa | 431 aa | 34.6 % |
Brugia malayi | Matrixin family protein | matrix metallopeptidase 1 (interstitial collagenase) | 403 aa | 401 aa | 27.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase | 0.0335 | 1 | 1 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0163 | 0.2561 | 1 |
Brugia malayi | Matrixin family protein | 0.0178 | 0.3201 | 0.3201 |
Loa Loa (eye worm) | hypothetical protein | 0.0335 | 1 | 1 |
Loa Loa (eye worm) | matrixin family protein | 0.0178 | 0.3201 | 0.086 |
Onchocerca volvulus | Matrilysin homolog | 0.0163 | 0.2561 | 1 |
Schistosoma mansoni | camp-specific cyclic nucleotide phosphodiesterase | 0.0335 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.031 | 0.8914 | 0.854 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0268 | 0.71 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.031 | 0.8914 | 0.854 |
Loa Loa (eye worm) | hypothetical protein | 0.031 | 0.8914 | 0.854 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0268 | 0.71 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 18 nM | Inhibition of human Matrix metalloproteinase-3 | ChEMBL. | 12217351 |
Ki (binding) | = 0.018 uM | Binding affinity for matrix metalloproteinase-3 | ChEMBL. | 10229623 |
Ki (binding) | = 0.018 uM | Inhibition of human stromelysin-1 (MMP-3) | ChEMBL. | 15163188 |
Ki (binding) | = 0.018 uM | Binding affinity for matrix metalloproteinase-3 | ChEMBL. | 10229623 |
Ki (binding) | = 0.018 uM | Inhibition of human stromelysin-1 (MMP-3) | ChEMBL. | 15163188 |
Ki (binding) | = 3 uM | Binding affinity for matrix metalloproteinase-1 | ChEMBL. | 10229623 |
Ki (binding) | = 3 uM | Inhibition of human Matrix metalloproteinase-2 (gelatinase-A) | ChEMBL. | 15163188 |
Ki (binding) | = 3 uM | Binding affinity for matrix metalloproteinase-1 | ChEMBL. | 10229623 |
Ki (binding) | = 3 uM | Inhibition of human Matrix metalloproteinase-2 (gelatinase-A) | ChEMBL. | 15163188 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
3 literature references were collected for this gene.