Detailed information for compound 552126

Basic information

Technical information
  • TDR Targets ID: 552126
  • Name: 7-chloro-6-hydroxy-3',4-dimethoxy-5'-methyl-s piro[benzofuran-2,4'-cyclohex-2-ene]-1',3-dio ne
  • MW: 338.74 | Formula: C16H15ClO6
  • H donors: 1 H acceptors: 3 LogP: 2.07 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC1=CC(=O)CC(C21Oc1c(C2=O)c(OC)cc(c1Cl)O)C
  • InChi: 1S/C16H15ClO6/c1-7-4-8(18)5-11(22-3)16(7)15(20)12-10(21-2)6-9(19)13(17)14(12)23-16/h5-7,19H,4H2,1-3H3
  • InChiKey: SYNGDIBHUPXIQA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 7-chloro-6-hydroxy-3',4-dimethoxy-5'-methylspiro[benzofuran-2,4'-cyclohex-2-ene]-1',3-dione
  • 7-chloro-6-hydroxy-3',4-dimethoxy-5'-methyl-spiro[1-benzofuran-2,4'-cyclohex-2-ene]-1',3-dione
  • 7-chloro-6-hydroxy-3',4-dimethoxy-5'-methyl-spiro[coumaran-2,4'-cyclohex-2-ene]-1',3-quinone
  • 7-chloro-6-hydroxy-3',4-dimethoxy-5'-methylspiro[1-benzofuran-2,4'-cyclohex-2-ene]-1',3-dione
  • 6-demethylgriseofulvin
  • 7-chloro-6-hydroxy-3',4-dimethoxy-5'-methyl-spiro[benzofuran-2,4'-cyclohex-2-ene]-1',3-quinone
  • 20168-88-1
  • (1'S-trans)-7-Chloro-6-hydroxy-2',4-dimethoxy-6'-methylspiro(benzofuran-2(3H),1'-(2)cyclohexen e)-3,4'-dione
  • 6-Desmethylgriseofulvin
  • Spiro[benzofuran-2(3H),1'-[2]cyclohexene]-3,4'-dione, 7-chloro-6-hydroxy-2',4-dimethoxy-6'-methyl-, (1'S-trans)-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus sterol regulatory element binding protein 0.0085 0.0145 0.0757
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0249 0.0643 0.1334
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0249 0.0643 1
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0249 0.0643 1
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0249 0.0643 0.7702
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0249 0.0643 0.1334
Plasmodium vivax phosphodiesterase gamma, putative 0.0249 0.0643 1
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0249 0.0643 1
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0102 0.0198 0.2196
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0249 0.0643 0.7702
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0249 0.0643 1
Loa Loa (eye worm) hypothetical protein 0.3082 0.9245 0.9242
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0249 0.0643 0.1334
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0249 0.0643 0.0643
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0053 0.0049 0.0358
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0249 0.0643 0.0643
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0249 0.0643 0.3359
Trichomonas vaginalis conserved hypothetical protein 0.0249 0.0643 1
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0085 0.0145 0.0113
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0249 0.0643 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0249 0.0643 1
Loa Loa (eye worm) hypothetical protein 0.3331 1 1
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0249 0.0643 0.7702
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0249 0.0643 1
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0249 0.0643 0.1334
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0249 0.0643 0.3359
Echinococcus granulosus Niemann Pick C1 protein 0.0282 0.0744 0.3884
Schistosoma mansoni hypothetical protein 0.0082 0.0136 0.0136
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0249 0.0643 1
Loa Loa (eye worm) PDE1B protein 0.0249 0.0643 0.0613
Loa Loa (eye worm) hypothetical protein 0.0153 0.0353 0.0322
Schistosoma mansoni kinase 0.0046 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0249 0.0643 0.0613
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0249 0.0643 0.0643
Onchocerca volvulus Serine\/threonine kinase homolog 0.0091 0.0165 1
Toxoplasma gondii leucyl aminopeptidase LAP 0.0102 0.0198 0.262
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0249 0.0643 1
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0249 0.0643 0.3359
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0249 0.0643 1
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0147 0.0333 0.3871
Leishmania major hypothetical protein, conserved 0.0249 0.0643 0.7668
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0249 0.0643 1
Leishmania major cAMP-specific phosphodiesterase, putative 0.0249 0.0643 0.7668
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0032 0.0659
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0032 0.0032
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0249 0.0643 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0249 0.0643 1
Trypanosoma cruzi hypothetical protein, conserved 0.0249 0.0643 0.7702
Trypanosoma cruzi hypothetical protein, conserved 0.0249 0.0643 0.7702
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0091 0.0165 0.0863
Entamoeba histolytica acyl-coA synthetase, putative 0.0047 0.0032 0.0659
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0249 0.0643 0.1334
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0249 0.0643 1
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0032 0.0032
Schistosoma mansoni niemann-pick C1 (NPC1) 0.02 0.0496 0.0496
Trypanosoma cruzi hypothetical protein, conserved 0.0249 0.0643 0.7702
Schistosoma mansoni hypothetical protein 0.0082 0.0136 0.0136
Echinococcus multilocularis expressed conserved protein 0.0185 0.045 0.0934
Leishmania major mitochondrial DNA polymerase beta 0.031 0.0829 1
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0249 0.0643 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0249 0.0643 0.7702
Echinococcus multilocularis microtubule associated protein 2 0.0668 0.1914 0.3972
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0249 0.0643 0.7702
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0165 0.2267
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0249 0.0643 1
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0249 0.0643 0.7668
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.3331 1 1
Schistosoma mansoni microtubule-associated protein tau 0.0668 0.1914 0.1914
Echinococcus multilocularis protein patched 0.0085 0.0145 0.0301
Loa Loa (eye worm) hypothetical protein 0.3082 0.9245 0.9242
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0249 0.0643 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0163 0.0384 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0249 0.0643 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0249 0.0643 1
Trichomonas vaginalis conserved hypothetical protein 0.0249 0.0643 1
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.3331 1 1
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0249 0.0643 0.3359
Echinococcus granulosus Niemann Pick C1 protein 0.0197 0.0487 0.2542
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0249 0.0643 1
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0249 0.0643 1
Echinococcus multilocularis muscleblind protein 1 0.0153 0.0353 0.0733
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0249 0.0643 1
Trypanosoma cruzi cytosolic leucyl aminopeptidase, putative 0.0102 0.0198 0.2196
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0249 0.0643 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0249 0.0643 1
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0249 0.0643 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0249 0.0643 1
Loa Loa (eye worm) hypothetical protein 0.3082 0.9245 0.9242
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0249 0.0643 1
Trypanosoma brucei mitochondrial DNA polymerase beta 0.031 0.0829 1
Mycobacterium ulcerans hypothetical protein 0.0163 0.0384 1
Trypanosoma cruzi polo-like protein kinase, putative 0.0091 0.0165 0.1794
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0249 0.0643 0.0643
Echinococcus granulosus microtubule associated protein 2 0.0668 0.1914 1
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0249 0.0643 1
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0249 0.0643 1
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0249 0.0643 0.3359
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0249 0.0643 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0282 0.0744 0.1543
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0249 0.0643 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0249 0.0643 1
Trypanosoma cruzi hypothetical protein, conserved 0.0249 0.0643 0.7702
Echinococcus multilocularis muscleblind protein 0.0153 0.0353 0.0733
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0249 0.0643 0.7702
Schistosoma mansoni hypothetical protein 0.0082 0.0136 0.0136
Echinococcus granulosus leucine aminopeptidase protein 0.0102 0.0198 0.1033
Trichomonas vaginalis conserved hypothetical protein 0.0085 0.0145 0.1936
Brugia malayi serine/threonine-protein kinase plk-2 0.0091 0.0165 0.0165
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0249 0.0643 0.1334
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0091 0.0165 0.0343
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0165 0.2267
Brugia malayi Niemann-Pick C1 protein precursor 0.0197 0.0487 0.0487
Echinococcus multilocularis Niemann Pick C1 protein 0.0197 0.0487 0.101
Echinococcus multilocularis sterol regulatory element binding protein 0.0085 0.0145 0.0301
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0249 0.0643 0.3359
Echinococcus multilocularis protein dispatched 1 0.0097 0.0181 0.0376
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0249 0.0643 1
Loa Loa (eye worm) hypothetical protein 0.0153 0.0353 0.0322
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0249 0.0643 0.0643
Leishmania major hypothetical protein, conserved 0.0249 0.0643 0.7668
Mycobacterium leprae Probable cytosol aminopeptidase PepB 0.0102 0.0198 1
Loa Loa (eye worm) hypothetical protein 0.0104 0.0203 0.0171
Echinococcus multilocularis G protein coupled receptor 139 0.0436 0.1213 0.2517
Trypanosoma cruzi hypothetical protein, conserved 0.0249 0.0643 0.7702
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0249 0.0643 0.0643
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0249 0.0643 1
Giardia lamblia Hypothetical protein 0.0249 0.0643 1
Schistosoma mansoni patched 1 0.0085 0.0145 0.0145
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0249 0.0643 1
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0249 0.0643 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0249 0.0643 1
Echinococcus granulosus expressed conserved protein 0.0185 0.045 0.2352
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0249 0.0643 1
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0249 0.0643 0.7702
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0249 0.0643 1
Plasmodium falciparum phosphodiesterase delta, putative 0.0249 0.0643 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0249 0.0643 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0249 0.0643 0.7702
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0249 0.0643 0.7702
Echinococcus granulosus neuropeptide receptor 0.0436 0.1213 0.6336
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0249 0.0643 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0249 0.0643 1
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0249 0.0643 0.7702
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0249 0.0643 0.0643
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0165 0.2267
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17, putative 0.0102 0.0198 0.2196
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0249 0.0643 1
Echinococcus multilocularis leucine aminopeptidase protein 0.0102 0.0198 0.041
Schistosoma mansoni serine/threonine protein kinase 0.0091 0.0165 0.0165
Chlamydia trachomatis cytosol aminopeptidase 0.0102 0.0198 0.5
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0249 0.0643 1
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0249 0.0643 1
Mycobacterium tuberculosis Probable aminopeptidase PepB 0.0102 0.0198 0.4715
Plasmodium falciparum phosphodiesterase gamma, putative 0.0249 0.0643 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0249 0.0643 1
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0165 0.2267
Wolbachia endosymbiont of Brugia malayi leucyl aminopeptidase 0.0102 0.0198 0.5
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0249 0.0643 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0249 0.0643 1
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0091 0.0165 0.1672
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0147 0.0333 0.378
Schistosoma mansoni neuropeptide receptor 0.0436 0.1213 0.1213
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0249 0.0643 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0249 0.0643 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0249 0.0643 1
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0249 0.0643 0.7702
Echinococcus multilocularis neuropeptide receptor 0.0436 0.1213 0.2517
Trypanosoma brucei hypothetical protein, conserved 0.0249 0.0643 0.7702
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0249 0.0643 0.0643
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0249 0.0643 1
Trichomonas vaginalis conserved hypothetical protein 0.0249 0.0643 1
Trypanosoma cruzi polo-like protein kinase, putative 0.0091 0.0165 0.1794
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0249 0.0643 1
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0091 0.0165 0.0134
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0165 0.2267
Echinococcus granulosus muscleblind protein 0.0153 0.0353 0.1846
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0249 0.0643 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0249 0.0643 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.031 0.0829 1
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0249 0.0643 0.7702
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0249 0.0643 0.3359
Brugia malayi Muscleblind-like protein 0.0153 0.0353 0.0353
Loa Loa (eye worm) hypothetical protein 0.0249 0.0643 0.0613
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0249 0.0643 0.0643
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0249 0.0643 1
Loa Loa (eye worm) hypothetical protein 0.0085 0.0145 0.0113
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0249 0.0643 1
Mycobacterium ulcerans leucyl aminopeptidase 0.0102 0.0198 0.4715
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0249 0.0643 0.0643
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0249 0.0643 1
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0249 0.0643 0.1334
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0249 0.0643 0.7702
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0249 0.0643 0.0643
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0197 0.0487 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0147 0.0333 0.3871
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0249 0.0643 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0249 0.0643 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0249 0.0643 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0249 0.0643 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0249 0.0643 1
Loa Loa (eye worm) hypothetical protein 0.0197 0.0487 0.0456
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0249 0.0643 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0249 0.0643 0.0643
Trypanosoma brucei polo-like protein kinase 0.0091 0.0165 0.1794
Loa Loa (eye worm) hypothetical protein 0.0249 0.0643 0.0613
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0249 0.0643 0.0643
Entamoeba histolytica serine/threonine protein kinase, putative 0.0091 0.0165 0.3397
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0249 0.0643 0.3359
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0249 0.0643 0.1334
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0249 0.0643 0.0643
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0165 0.2267
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0249 0.0643 1
Brugia malayi CHE-14 protein 0.0085 0.0145 0.0145
Schistosoma mansoni hypothetical protein 0.0082 0.0136 0.0136
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0249 0.0643 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0249 0.0643 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0249 0.0643 1
Trypanosoma cruzi hypothetical protein, conserved 0.0249 0.0643 0.7702
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0032 0.0659
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0032 0.0032
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0249 0.0643 1
Giardia lamblia hypothetical protein 0.0249 0.0643 1
Leishmania major cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 0.0102 0.0198 0.208
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0249 0.0643 0.7702
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0165 0.2267
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.031 0.0829 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1625 0.482 1
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0249 0.0643 0.0643
Echinococcus granulosus Protein patched homolog 1 0.0085 0.0145 0.0757

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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