Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0046 | 1 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0046 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0046 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0046 | 1 | 1 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0024 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 1 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0046 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0046 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 1 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0046 | 1 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0046 | 1 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0046 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0046 | 1 | 1 |
Brugia malayi | steroid hormone receptor | 0.0046 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0046 | 1 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0046 | 1 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0046 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0046 | 1 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0046 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0046 | 1 | 1 |
Brugia malayi | nuclear receptor RXR | 0.0024 | 0.1071 | 0.1071 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0046 | 1 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0046 | 1 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0046 | 1 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0046 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0046 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0024 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0046 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0046 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0046 | 1 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0046 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0046 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0024 | 0.1071 | 0.1071 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0046 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0046 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0046 | 1 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0046 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0046 | 1 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0046 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0046 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0046 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0046 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0024 | 0.1071 | 0.1071 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0046 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0046 | 1 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0046 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0046 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0046 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.1071 | 0.1071 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0046 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0046 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0024 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 1 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0046 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0024 | 0.1071 | 0.1071 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0046 | 1 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0046 | 1 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0046 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0024 | 0.1071 | 0.1071 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0046 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.1071 | 0.1071 |
Schistosoma mansoni | nuclear hormone receptor | 0.0046 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0046 | 1 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0046 | 1 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0046 | 1 | 1 |
Onchocerca volvulus | 0.0046 | 1 | 1 | |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0024 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.1071 | 0.1071 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0046 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0046 | 1 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0046 | 1 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0046 | 1 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0046 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0046 | 1 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0046 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0046 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0046 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0024 | 0.1071 | 0.1071 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
clogP | = 3.19 | Calculated partition coefficient (clogP) (PALLAS) | ChEMBL. | 9154974 |
I (functional) | = 17.5 % | Inhibitory effect on L-tri-iodothyronine (L-T3) uptake by human HepG2 hepatoma cells at an application dose 10E-5 M | ChEMBL. | 9154974 |
I (functional) | = 17.5 % | Inhibitory effect on L-tri-iodothyronine (L-T3) uptake by human HepG2 hepatoma cells at an application dose 10E-5 M | ChEMBL. | 9154974 |
Inhibition (functional) | = 44 % | Antagonist activity at rat Cav1.3 expressed in HEK293 cells assessed as inhibition of voltage pulse-induced calcium current at 200 nM by FLIPR calcium 4 assay | ChEMBL. | 20382537 |
Inhibition (functional) | = 69 % | Antagonist activity at rabbit Cav1.2 expressed in HEK293 cells assessed as inhibition of voltage pulse-induced calcium current at 200 nM by FLIPR calcium 4 assay | ChEMBL. | 20382537 |
logP (ADMET) | = 3.22 | Partition coefficient (logP) | ChEMBL. | 9154974 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.